Changes in the concentration and composition of plasma lipoproteins during the acute phase response

被引:110
作者
Carpentier, YA [1 ]
Scruel, O [1 ]
机构
[1] Free Univ Brussels, L Deloyers Lab Expt Surg, B-1070 Brussels, Belgium
关键词
D O I
10.1097/00075197-200203000-00006
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The acute phase reactions, associated with injury, inflammation, or sepsis, markedly affect the concentration and composition of plasma lipids and lipoproteins. Hepatic production of triglycerides and very low density lipoprotein formation are increased, but do not necessarily result in high plasma triglyceride levels. In contrast, all conditions lower plasma cholesterol by decreasing its content in both low-density and high-density lipoproteins. In addition, substantial changes in protein and lipid composition of lipoproteins are observed that may redefine the function of these particles, but also increase their atherogenic and inflammatory properties. (C) 2002 Lippincott Williams Wilkins.
引用
收藏
页码:153 / 158
页数:6
相关论文
共 55 条
[51]   Rabbit aorta and human atherosclerotic lesions hydrolyze the sphingomyelin of retained low-density lipoprotein - Proposed role for arterial-wall sphingomyelinase in subendothelial retention and aggregation of atherogenic lipoproteins [J].
Schissel, SL ;
TweedieHardman, J ;
Rapp, JH ;
Graham, G ;
Williams, KJ ;
Tabas, I .
JOURNAL OF CLINICAL INVESTIGATION, 1996, 98 (06) :1455-1464
[52]   Atheroprotective mechanisms of HDL [J].
Stein, O ;
Stein, Y .
ATHEROSCLEROSIS, 1999, 144 (02) :285-301
[53]   Enhanced oxidative susceptibility and reduced antioxidant content of metabolic precursors of small, dense low-density lipoproteins [J].
Tribble, DL ;
Rizzo, M ;
Chait, A ;
Lewis, DM ;
Blanche, PJ ;
Krauss, RM .
AMERICAN JOURNAL OF MEDICINE, 2001, 110 (02) :103-110
[54]   Role of reactive aldehyde in cardiovascular diseases [J].
Uchida, K .
FREE RADICAL BIOLOGY AND MEDICINE, 2000, 28 (12) :1685-1696
[55]  
Van Berkel Theo J. C., 1994, Current Opinion in Lipidology, V5, P331, DOI 10.1097/00041433-199410000-00004