Structured treatment interruptions in HIV/AIDS therapy

被引:31
作者
Lisziewicz, J
Lori, F
机构
[1] IRCCS, Policlinico S Matteo, RIGHT, I-27100 Pavia, Italy
[2] RIGHT, Washington, DC USA
关键词
AIDS; immunotherapy; immune reconstitution; vaccine;
D O I
10.1016/S1286-4579(01)01529-5
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Structured treatment interruption (STI) has been investigated for three distinct clinical scenarios: during acute infection with the goal of immune reconstitution and auto immunization; during chronic infection, to decrease the amount and toxicity of antiretroviral drugs; and during virologic failure to restore response to subsequent antiretroviral therapy. The potential costs and benefits of STI should be determined. (C) 2002 Editions scientifiques et medicales Elsevier SAS. All rights reserved.
引用
收藏
页码:207 / 214
页数:8
相关论文
共 35 条
[1]   Transient mobilization of human immunodeficiency virus (HIV)-specific CD4 T-helper cells fails to control virus rebounds during intermittent antiretroviral therapy in chronic HIV type 1 infection [J].
Carcelain, G ;
Tubiana, R ;
Samri, A ;
Calvez, V ;
Delaugerre, C ;
Agut, H ;
Katlama, C ;
Autran, B .
JOURNAL OF VIROLOGY, 2001, 75 (01) :234-241
[2]   Adverse effects of antiretroviral therapy [J].
Carr, A ;
Cooper, DA .
LANCET, 2000, 356 (9239) :1423-1430
[3]   Skewed maturation of memory HIV-specific CD8 T lymphocytes [J].
Champagne, P ;
Ogg, GS ;
King, AS ;
Knabenhans, C ;
Ellefsen, K ;
Nobile, M ;
Appay, V ;
Rizzardi, GP ;
Fleury, S ;
Lipp, M ;
Förster, R ;
Rowland-Jones, S ;
Sékaly, RP ;
McMichael, AJ ;
Pantaleo, G .
NATURE, 2001, 410 (6824) :106-111
[4]  
COHEN J, 1997, SCIENCE, V277
[5]   Acute HIV syndrome after discontinuation of antiretroviral therapy in a patient treated before seroconversion [J].
Daar, ES ;
Bai, JX ;
Hausner, MA ;
Majchrowicz, M ;
Tamaddon, M ;
Giorgi, JV .
ANNALS OF INTERNAL MEDICINE, 1998, 128 (10) :827-829
[6]   HIV-1 and T cell dynamics after interruption of highly active antiretroviral therapy (HAART) in patients with a history of sustained viral suppression [J].
Davey, RT ;
Bhat, N ;
Yoder, C ;
Chun, TW ;
Metcalf, JA ;
Dewar, R ;
Natarajan, V ;
Lempicki, RA ;
Adelsberger, JW ;
Millers, KD ;
Kovacs, JA ;
Polis, MA ;
Walker, RE ;
Falloon, L ;
Masur, H ;
Gee, D ;
Baseler, M ;
Dimitrov, DS ;
Fauci, AS ;
Lane, HC .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (26) :15109-15114
[7]  
DYBUL M, 2001, 8 C RETR OPP INF
[8]  
EEKS SG, 2001, NEW ENGL J MED, V344, P472
[9]  
FAGARD C, 2001, 8 C RETR OPP INF
[10]   The virological and immunological consequences of structured treatment interruptions in chronic HIV-1 infection [J].
García, F ;
Plana, M ;
Ortiz, GM ;
Bonhoeffer, S ;
Soriano, A ;
Vidal, C ;
Cruceta, A ;
Arnedo, M ;
Gil, C ;
Pantaleo, G ;
Pumarola, T ;
Gallart, T ;
Nixon, DF ;
Miró, JM ;
Gatell, JM .
AIDS, 2001, 15 (09) :F29-F40