Structured treatment interruptions in HIV/AIDS therapy

被引:31
作者
Lisziewicz, J
Lori, F
机构
[1] IRCCS, Policlinico S Matteo, RIGHT, I-27100 Pavia, Italy
[2] RIGHT, Washington, DC USA
关键词
AIDS; immunotherapy; immune reconstitution; vaccine;
D O I
10.1016/S1286-4579(01)01529-5
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Structured treatment interruption (STI) has been investigated for three distinct clinical scenarios: during acute infection with the goal of immune reconstitution and auto immunization; during chronic infection, to decrease the amount and toxicity of antiretroviral drugs; and during virologic failure to restore response to subsequent antiretroviral therapy. The potential costs and benefits of STI should be determined. (C) 2002 Editions scientifiques et medicales Elsevier SAS. All rights reserved.
引用
收藏
页码:207 / 214
页数:8
相关论文
共 35 条
[21]  
Margolis D, 1999, J ACQ IMMUN DEF SYND, V21, P362
[22]   ALTERATIONS OF T-CELL RECEPTOR VARIABLE REGION EXPRESSION IN HUMAN-IMMUNODEFICIENCY-VIRUS DISEASE [J].
MCCOY, JP ;
OVERTON, WR ;
BLUMSTEIN, L ;
BAXTER, JD ;
GEKOWSKI, KM ;
DONALDSON, MH .
CYTOMETRY, 1995, 22 (01) :1-9
[23]   The dynamics of CD4+ T-cell depletion in HIV disease [J].
McCune, JM .
NATURE, 2001, 410 (6831) :974-979
[24]   Structured treatment interruptions in antiretroviral management of HIV-1 [J].
Miller, V .
CURRENT OPINION IN INFECTIOUS DISEASES, 2001, 14 (01) :29-37
[25]   Virological and immunological effects of treatment interruptions in HIV-1 infected patients with treatment failure [J].
Miller, V ;
Sabin, C ;
Hertogs, K ;
Bloor, S ;
Martinez-Picado, J ;
D'Aquila, R ;
Larder, B ;
Lutz, T ;
Gute, P ;
Weidmann, E ;
Rabenau, H ;
Phillips, A ;
Staszewski, S .
AIDS, 2000, 14 (18) :2857-2867
[26]   Rapid activation of lymph nodes and mononuclear cell HIV expression upon interrupting highly active antiretroviral therapy in patients after prolonged viral suppression [J].
Orenstein, JM ;
Bhat, N ;
Yoder, C ;
Fox, C ;
Polis, MA ;
Metcalf, JA ;
Kovacs, JA ;
Falloon, J ;
Walker, RE ;
Masur, H ;
Lane, HC ;
Davey, RT .
AIDS, 2000, 14 (12) :1709-1715
[27]   HIV-1-specific immune responses in subjects who temporarily contain virus replication after discontinuation of highly active antiretroviral therapy [J].
Ortiz, GM ;
Nixon, DF ;
Trkola, A ;
Binley, J ;
Jin, X ;
Bonhoeffer, S ;
Kuebler, PJ ;
Donahoe, SM ;
Demoitie, MA ;
Kakimoto, WM ;
Ketas, T ;
Clas, B ;
Heymann, JJ ;
Zhang, LQ ;
Cao, YZ ;
Hurley, A ;
Moore, JP ;
Ho, DD ;
Markowitz, M .
JOURNAL OF CLINICAL INVESTIGATION, 1999, 104 (06) :R13-R18
[28]   Enhancement of human immunodeficiency virus type 1-specific CD4 and CD8 T cell responses in chronically infected persons after temporary treatment interruption [J].
Papasavvas, E ;
Ortiz, GM ;
Gross, R ;
Sun, JW ;
Moore, EC ;
Heymann, JJ ;
Moonis, M ;
Sandberg, JK ;
Drohan, LA ;
Gallagher, B ;
Shull, J ;
Nixon, DF ;
Kostman, JR ;
Montaner, LJ .
JOURNAL OF INFECTIOUS DISEASES, 2000, 182 (03) :766-775
[29]   Reservoirs for HIV-1: Mechanisms for viral persistence in the presence of antiviral immune responses and antiretroviral therapy [J].
Pierson, T ;
McArthur, T ;
Siliciano, RF .
ANNUAL REVIEW OF IMMUNOLOGY, 2000, 18 :665-708
[30]  
PLANA M, 2001, 8 C RETR OPP INF