Retinitis pigmentosa: cone photoreceptors starving to death

被引：29

作者：

Bovolenta, Paola ^{[1
,2
]}

Cisneros, Elsa ^{[1
,2
]}

机构：

[1] CSIC, Inst Cajal, Dept Neurobiol Mol Celular & Desarrollo, E-28002 Madrid, Spain

[2] CIBER Enfermedades Raras, Madrid, Spain

来源：

NATURE NEUROSCIENCE | 2009年 / 12卷 / 01期

关键词：

ROD; MOUSE;

D O I：

10.1038/nn0109-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

In retinitis pigmentosa, rod and cone photoreceptors die. Although rods die as a consequence of rod-specific genetic mutations, there is no clear explanation for the progressive loss of cones. A new study in this issue suggests that changes in the insulin/mTOR pathway and cell starvation can partially account for cone death in this disease.

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收藏

页码：5 / 7

页数：3

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