Retinal degenerations:: From cell signaling to cell therapy;: Pre-clinical and clinical issues

被引：29

作者：

Cronin, Therese ^{[1
]}

Leveillard, Thierry ^{[1
]}

Sahel, Jose-Alain ^{[1
]}

机构：

[1] Univ Paris 06, Lab Physiopathol Cellulaire & Mol Retine, INSERM, U592, F-75252 Paris 05, France

来源：

CURRENT GENE THERAPY | 2007年 / 7卷 / 02期

关键词：

D O I：

10.2174/156652307780363143

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Extracellular signaling molecules have been implicated in the progression of Retinal Degeneration (RD). Gene regulatory events linked to the maintenance of retinal structure and function incorporate signaling cascades that may serve as therapeutic targets for some forms of blindness. This review shall focus on the evidence for non-cell-autonomous mechanisms that affect the pattern of degeneration seen in retinal dystrophies, the types of signals that may influence the course of degeneration and finally with the related prospects for retinal-therapies.

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页码：121 / 129

页数：9

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