Aripiprazole:: Pharmacodynamics of a dopamine partial agonist for the treatment of schizophrenia

被引：49

作者：

Gründer, G ^{[1
]}

Kungel, M ^{[1
]}

Ebrecht, M ^{[1
]}

Göröcs, T ^{[1
]}

Modell, S ^{[1
]}

机构：

[1] Rhein Westfal TH Aachen, Univ Klinikum Aachen, Klin Psychiat & Psychotherapy, D-52074 Aachen, Germany

来源：

PHARMACOPSYCHIATRY | 2006年 / 39卷

关键词：

D O I：

10.1055/s-2006-931485

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Aripiprazole is the first approved atypical antipsychotic with a mechanism of action that exerts a partial agonism with high affinity at Dopamin D-2- and Serotonin-5-HT1A-receptors as well as an antagonism at Serotonin-5-HT2A-receptors. Aripiprazole provides good clinical effectiveness and a favorable profile of safety and tolerability. The special pharmacodynamics of aripiprazole are described herein.

引用

页码：S21 / S25

页数：5

共 22 条

[1]

AUBY P, 2002, 15 EUR COLL NEUR C E

[2]

Bandelow B., 2003, GERMAN J PSYCHIAT, V6, P9

[3]

Carlsson A, 1978, Am J Psychiatry, V135, P165

[4]

CORNBLATT B, 2001, MOUNT SIN C COGN SCH

[5] A functional genetic variation of the 5-HT2a receptor affects human memory [J].

de Quervain, DJF ;

Henke, K ;

Aerni, A ;

Coluccia, D ;

Wollmer, MA ;

Hock, C ;

Nitsch, RM ;

Papassotiropoulos, A .

NATURE NEUROSCIENCE, 2003, 6 (11) :1141-1142

[6]

FARDE L, 1988, ARCH GEN PSYCHIAT, V45, P71

[7] Mechanism of new antipsychotic medications -: Occupancy is not just antagonism [J].

Gründer, G ;

Carlsson, A ;

Wong, DF .

ARCHIVES OF GENERAL PSYCHIATRY, 2003, 60 (10) :974-977

[8]

GRUNDER G, 2002, NERVENARZT S1, V73, pS191

[9] Elevated anxiety and antidepressant-like responses in serotonin 5-HT1A receptor mutant mice [J].

Heisler, LK ;

Chu, HM ;

Brennan, TJ ;

Danao, JA ;

Bajwa, P ;

Parsons, LH ;

Tecott, LH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (25) :15049-15054

[10]

HIPPIUS H, 2002, EUR ARCH PSYCHIAT S1, V252, pS51

← 1 2 3 →