Marked increase in number of dendritic cells in autoimmune-prone (NZW x BXSB)F1 mice with age

被引：25

作者：

Adachi, Y

Taketani, S

Toki, J

Ikebukuro, K

Sugiura, K

Oyaizu, H

Yasumizu, R

Tomita, M

Kaneda, H

Amoh, Y

Ito, T

Okigaki, M

Inaba, M

Ikehara, S

机构：

[1] Kansai Med Univ, Dept Pathol 1, Moriguchi, Osaka 5708506, Japan

[2] Kyoto Inst Technol, Dept Biotechnol, Sakyo Ku, Kyoto 606, Japan

[3] Kansai Med Univ, Dept Internal Med 3, Moriguchi, Osaka 570, Japan

[4] Kansai Med Univ, Dept Internal Med 1, Moriguchi, Osaka 5708506, Japan

[5] Kansai Med Univ, Dept Internal Med 2, Moriguchi, Osaka 5708506, Japan

来源：

STEM CELLS | 2002年 / 20卷 / 01期

关键词：

autoimmune disease; dendritic cell; Flt-3; ligand; (NZW x BXSB)F1 mouse;

D O I：

10.1634/stemcells.20-1-61

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Here we report that the number of CD11c(+)CD3(-)B220(-) cells increases in autoimmune-prone male (NZW x BXSB)F1 (W/BF1) mice with age. The CD11c(+)CD3(-)B220(-) cells from W/BF1 mice show a typical stellate shape and induce the proliferation of T cells. In the CD11c(+)CD3(-)B220(-) cells from W/BF1 mice, CD11b (Mac-1alpha), NK 1.1, and CD95 (Fas) are upregulated in comparison with normal mice, while the expression of CD8alpha, CD117 (c-kit), CD135 (Flk-2/Flt-3), and Sca-1 decreases. There is a significant increase in Flt-3L (FL) mRNA in the bone marrow of W/BF1 mice with of age. Moreover, activated hemopoietic cells express high levels of FL. The injection of CD11c(+)CD3(-)B220(-) cells from old W/BF1 mice to young W/BF1 mice transiently induces autoimmune disease (thrombocytopenia). These results suggest that hyperproduction of FL from activated hemopoietic cells induces a dramatic increase in the number of dendritic cells in aged W/BF1 mice, followed by the acceleration of autoimmunity.

引用

页码：61 / 72

页数：12

共 33 条

[1] EFFECT OF BONE-MARROW TRANSPLANTATION ON ANTIPHOSPHOLIPID ANTIBODY SYNDROME IN MURINE LUPUS MICE [J].