Marked increase in number of dendritic cells in autoimmune-prone (NZW x BXSB)F1 mice with age

被引:25
作者
Adachi, Y
Taketani, S
Toki, J
Ikebukuro, K
Sugiura, K
Oyaizu, H
Yasumizu, R
Tomita, M
Kaneda, H
Amoh, Y
Ito, T
Okigaki, M
Inaba, M
Ikehara, S
机构
[1] Kansai Med Univ, Dept Pathol 1, Moriguchi, Osaka 5708506, Japan
[2] Kyoto Inst Technol, Dept Biotechnol, Sakyo Ku, Kyoto 606, Japan
[3] Kansai Med Univ, Dept Internal Med 3, Moriguchi, Osaka 570, Japan
[4] Kansai Med Univ, Dept Internal Med 1, Moriguchi, Osaka 5708506, Japan
[5] Kansai Med Univ, Dept Internal Med 2, Moriguchi, Osaka 5708506, Japan
关键词
autoimmune disease; dendritic cell; Flt-3; ligand; (NZW x BXSB)F1 mouse;
D O I
10.1634/stemcells.20-1-61
中图分类号
Q813 [细胞工程];
学科分类号
摘要
Here we report that the number of CD11c(+)CD3(-)B220(-) cells increases in autoimmune-prone male (NZW x BXSB)F1 (W/BF1) mice with age. The CD11c(+)CD3(-)B220(-) cells from W/BF1 mice show a typical stellate shape and induce the proliferation of T cells. In the CD11c(+)CD3(-)B220(-) cells from W/BF1 mice, CD11b (Mac-1alpha), NK 1.1, and CD95 (Fas) are upregulated in comparison with normal mice, while the expression of CD8alpha, CD117 (c-kit), CD135 (Flk-2/Flt-3), and Sca-1 decreases. There is a significant increase in Flt-3L (FL) mRNA in the bone marrow of W/BF1 mice with of age. Moreover, activated hemopoietic cells express high levels of FL. The injection of CD11c(+)CD3(-)B220(-) cells from old W/BF1 mice to young W/BF1 mice transiently induces autoimmune disease (thrombocytopenia). These results suggest that hyperproduction of FL from activated hemopoietic cells induces a dramatic increase in the number of dendritic cells in aged W/BF1 mice, followed by the acceleration of autoimmunity.
引用
收藏
页码:61 / 72
页数:12
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