Dialkynylpyrenes: Strongly Fluorescent, Environment-Sensitive DNA Building Blocks

被引：61

作者：

Bittermann, Holger ^{[1
]}

Siegemund, Doreen ^{[1
]}

Malinovskii, Vladimir L. ^{[1
]}

Haener, Robert ^{[1
]}

机构：

[1] Univ Bern, Dept Chem & Biochem, CH-3012 Bern, Switzerland

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2008年 / 130卷 / 46期

关键词：

D O I：

10.1021/ja806747h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Two isomeric dialkynylpyrene phosphoramidites and their incorporation into oligonucleotides are described. The pyrene units closely resemble the well-known perylene bisimide dye PDI with regard to the ability to self-organize within a DNA duplex. In addition, dialkynylpyrenes exhibit significant monomer and remarkably strong excimer fluorescence. The dialkynylpyrene building blocks are promising candidates for applications in diagnostic toots, such as excimer-based molecular beacons, as well as for novel DNA-based materials with special optical properties.

引用

页码：15285 / +

页数：4

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