A clean conversion of aldehydes to nitriles using a solid-supported hydrazine

被引：38

作者：

Baxendale, IR ^{[1
]}

Ley, SV ^{[1
]}

Sneddon, HF ^{[1
]}

机构：

[1] Univ Cambridge, Dept Chem, Cambridge CB2 1EW, England

来源：

SYNLETT | 2002年 / 05期

关键词：

aldehydes; nitriles; polymer-supported reagents;

D O I：

10.1055/s-2002-25333

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A polymer-supported hydrazine reagent has been applied to the conversion of a range of aldehydes to nitriles, providing a clean and efficient route to more diverse building blocks for combinatorial chemistry programmes.

引用

页码：775 / 777

页数：3

共 24 条

[1]

Brackman W., 1963, RECL TRAV CHIM PAY B, V82, P757

[2]

CAPDEVIELLE P, 1989, SYNTHESIS-STUTTGART, P451

[3]

Chen FE, 2000, SYNTHESIS-STUTTGART, P1519

[4] UBER DIE OXYDATION VON AROMATISCHEN ALDIMINEN IN FLUSSIGER PHASE [J].

FISCHER, E .

JOURNAL FUR PRAKTISCHE CHEMIE, 1965, 29 (3-6) :199-&

[5] NEUTRAL CONVERSION OF ALDOXIMES INTO NITRILES AT LOW-TEMPERATURE [J].

FOLEY, HG ;

DALTON, DR .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1973, (17) :628-629

[6] Effective transformation of aldoximes to nitriles by dehydration with 2-methylene-1,3-dioxepane in the presence of a Lewis acid catalyst [J].

Fukuzawa, S ;

Yamaishi, Y ;

Furuya, H ;

Terao, K ;

Iwasaki, F .

TETRAHEDRON LETTERS, 1997, 38 (41) :7203-7206

[7]

Hinzen B, 1998, SYNTHESIS-STUTTGART, P977

[8]

KUKHAR VP, 1974, SYNTHESIS-STUTTGART, P563

[9] Microwave promoted rapid dehydration of aldoximes to nitriles on a solid support [J].

Kumar, HMS ;

Mohanty, PK ;

Kumar, MS ;

Yadav, JS .

SYNTHETIC COMMUNICATIONS, 1997, 27 (08) :1327-1333

[10] Multi-step organic synthesis using solid-supported reagents and scavengers: a new paradigm in chemical library generation [J].

Ley, SV ;

Baxendale, IR ;

Bream, RN ;

Jackson, PS ;

Leach, AG ;

Longbottom, DA ;

Nesi, M ;

Scott, JS ;

Storer, RI ;

Taylor, SJ .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 2000, (23) :3815-4195

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