Effector pathways in immune mediated central nervous system demyelination

被引:46
作者
Kieseier, BC
Storch, MK
Archelos, JJ
Martino, G
Hartung, HP
机构
[1] Karl Franzens Univ Graz, Dept Neurol, A-8036 Graz, Austria
[2] Ist Sci San Raffaele, DIBIT, Dept Neurol, Expt Neuroimmunotherapy Unit, I-20132 Milan, Italy
关键词
D O I
10.1097/00019052-199906000-00011
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Multiple sclerosis is generally regarded to be a primarily T-cell driven disease. Recent evidence has refocused interest on antibodies. Adhesion molecules, matrix metalloproteinases, chemokines and cytokines, and nitric oxide and oxygen metabolites all participate in the amplification and effector stages of the disease. (C) 1999 Lippincott Williams & Wilkins.
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页码:323 / 336
页数:14
相关论文
共 129 条
[71]   Distinct patterns of multiple sclerosis pathology indicates heterogeneity in pathogenesis [J].
Lucchinetti, CF ;
Bruck, W ;
Rodriguez, M ;
Lassmann, H .
BRAIN PATHOLOGY, 1996, 6 (03) :259-274
[72]   Chemokines - Chemotactic cytokines that mediate inflammation [J].
Luster, AD .
NEW ENGLAND JOURNAL OF MEDICINE, 1998, 338 (07) :436-445
[73]   Matrix metalloproteinases in the normal human central nervous system, microglial nodules, and multiple sclerosis lesions [J].
Maeda, A ;
Sobel, RA .
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 1996, 55 (03) :300-309
[74]   Human matrix metalloprotease activation by insults of bacterial infection involving proteases and free radicals [J].
Maeda, H ;
Okamoto, T ;
Akaike, T .
BIOLOGICAL CHEMISTRY, 1998, 379 (02) :193-200
[75]  
Matyszak MK, 1996, J NEUROIMMUNOL, V69, P141
[76]   MCP-1, MCP-2 and MCP-3 expression in multiple sclerosis lesions: an immunohistochemical and in situ hybridization study [J].
McManus, C ;
Berman, JW ;
Brett, FM ;
Staunton, H ;
Farrell, M ;
Brosnan, CF .
JOURNAL OF NEUROIMMUNOLOGY, 1998, 86 (01) :20-29
[77]  
Mendel I, 1998, EUR J IMMUNOL, V28, P1727, DOI 10.1002/(SICI)1521-4141(199805)28:05<1727::AID-IMMU1727>3.0.CO
[78]  
2-#
[79]  
MIJAGISHI R, 1995, J NEUROL SCI, V129, P223
[80]   PROTECTION AGAINST A LETHAL DOSE OF ENDOTOXIN BY AN INHIBITOR OF TUMOR-NECROSIS-FACTOR PROCESSING [J].
MOHLER, KM ;
SLEATH, PR ;
FITZNER, JN ;
CERRETTI, DP ;
ALDERSON, M ;
KERWAR, SS ;
TORRANCE, DS ;
OTTENEVANS, C ;
GREENSTREET, T ;
WEERAWARNA, K ;
KRONHEIM, SR ;
PETERSEN, M ;
GERHART, M ;
KOZLOSKY, CJ ;
MARCH, CJ ;
BLACK, RA .
NATURE, 1994, 370 (6486) :218-220