Role of lipopolysaccharide susceptibility in the innate immune response to Salmonella typhimurium infection:: LPS, a primary target for recognition of Gram-negative bacteria

被引：49

作者：

Freudenberg, MA

Merlin, T

Gumenscheimer, M

Kalis, C

Landmann, R

Galanos, C

机构：

[1] Max Planck Inst Immunobiol, D-79108 Freiburg, Germany

[2] Univ Basel Hosp, Dept Res, Div Infect Dis, CH-4031 Basel, Switzerland

来源：

MICROBES AND INFECTION | 2001年 / 3卷 / 14-15期

关键词：

LPS susceptibility; lps gene; TNF-alpha; Salmonella typhimurium infection; LPS-binding protein; TLR4; CD14; IFN-gamma; IL-12;

D O I：

10.1016/S1286-4579(01)01481-2

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Lipopolysaccharide is an important recognition marker by virtue of which the innate immune system senses and reacts against Gram-negative bacteria invading the LPS susceptible host. This review deals with the factors affecting LPS susceptibility and with the role of the latter in the course and outcome of Salmonella typhimurium infection. (C) 2001 Editions scientifiques et medicales Elsevier SAS.

引用

页码：1213 / 1222

页数：10

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[1] Toll-like receptors: lessons from knockout mice [J].