Red propolis ameliorates ischemic-reperfusion acute kidney injury

被引：47

作者：

Bezerra da Costa, Marcus Felipe ^{[1
]}

Liborio, Alexandre Braga ^{[2
]}

Teles, Flavio ^{[3
]}

Martins, Conceicao da Silva ^{[4
]}

Gomes Soares, Pedro Marcos ^{[4
]}

Menesese, Gdayllon C. ^{[5
]}

de Paulo Rodrigues, Francisco Adelvane ^{[1
]}

Almeida Moreira Leal, Luzia Kalyne ^{[5
]}

Miron, Diogo ^{[5
]}

Silva, Aline Holanda ^{[5
]}

Costa Martins, Alice Maria ^{[5
]}

机构：

[1] Univ Fed Ceara, Fac Med, Dept Physiol & Pharmacol, Fortaleza, Ceara, Brazil

[2] Univ Fed Ceara, Fac Med, Dept Clin Med, Fortaleza, Ceara, Brazil

[3] Univ Fed Alagoas, BR-57072900 Maceio, AL, Brazil

[4] Univ Fed Ceara, Fac Med, Dept Morphol, Fortaleza, Ceara, Brazil

[5] Univ Fed Ceara, Fac Pharm, Dept Clin & Toxicol Anal, Fortaleza, Ceara, Brazil

来源：

PHYTOMEDICINE | 2015年 / 22卷 / 09期

关键词：

Acute kidney injury; Red propolis; Heme-oxygenase; PROTECTS; SEPSIS; PATHOPHYSIOLOGY; GENISTEIN; ERK1/2; RAT;

D O I：

10.1016/j.phymed.2015.03.017

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

Introduction: Acute kidney injury (AKI) remains a great problem in clinical practice. Renal is (I/R) injury is a complex pathophysiological process. Propolis is a natural polyphenol-rich resinous substance collected by honeybees from a variety of plant sources that has anti-inflammatory and anti-oxidative properties. Red propolis (RP) protection in renal I/R injury was investigated. Methods: Male Wistar rats underwent unilateral nephrectomy and contralateral renal I/R (60 min). Rats were divided into four groups: (1) sham group, (2) RP group (sham-operated rats treated with RP), 3) IR group (rats submitted to ischemia) and (4) IR-RP (rats treated with RP before ischemia). At 48 h after reperfusion, renal function was assessed and kidneys were removed for analysis. Results: I/R increased plasma levels of creatinine and reduced creatinine clearance (CrCl), and RP provided protection against this renal injury. Red propolis significantly improves oxidative stress parameters when compared with the IR group. Semiquantitative assessment of the histological lesions showed marked structural damage in I/R rats compared with the IR-RP rats. RP attenuates I/R-induced endothelial nitric oxide-synthase down regulation and increased heme-oxygenase expression in renal tissue. Conclusion: Red propolis protects kidney against acute ischemic renal failure and this protection is associated with reduced oxidative stress and eNOS and heme-oxygenase up regulation. (C) 2015 Elsevier GmbH. All rights reserved.

引用

页码：787 / 795

页数：9

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