Organic chemistry in drug discovery

被引：105

作者：

MacCoss, M

Baillie, TA

机构：

[1] Merck Res Labs, Dept Basic Chem, Rahway, NJ 07065 USA

[2] Merck Res Labs, Dept Drug Metab, W Point, PA 19486 USA

来源：

SCIENCE | 2004年 / 303卷 / 5665期

关键词：

D O I：

10.1126/science.1096800

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The role played by organic chemistry in the pharmaceutical industry continues to be one of the main drivers in the drug discovery process. However, the precise nature of that role is undergoing a visible change, not only because of the new synthetic methods and technologies now available to the synthetic and medicinal chemist, but also in several key areas, particularly in drug metabolism and chemical toxicology, as chemists deal with the ever more rapid turnaround of testing data that influences their day-to-day decisions.

引用

页码：1810 / 1813

页数：4

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