β-Cyclodextrin conjugated magnetic, fluorescent silica core-shell nanoparticles for biomedical applications

被引：75

作者：

Badruddoza, Abu Zayed Md. ^{[1
]}

Rahman, Md. Taifur ^{[2
]}

Ghosh, Sudipa ^{[1
]}

Hossain, Md. Zakir ^{[3
]}

Shi, Jizhong ^{[3
]}

Hidajat, Kus ^{[1
]}

Uddin, Mohammad Shahab ^{[4
]}

机构：

[1] Natl Univ Singapore, Dept Chem & Biomol Engn, Singapore 117576, Singapore

[2] Queens Univ Belfast, Sch Chem & Chem Engn, Belfast BT9 5AG, Antrim, North Ireland

[3] Natl Univ Singapore, Canc Sci Inst Singapore, Ctr Life Sci, Singapore 117456, Singapore

[4] Int Islamic Univ Malaysia, Fac Engn, Dept Biotechnol Engn, Kuala Lumpur 50728, Malaysia

来源：

CARBOHYDRATE POLYMERS | 2013年 / 95卷 / 01期

关键词：

Multifunctional magnetic nanoparticles; beta-Cyclodextrin; Fluorescent imaging; Cell targeting; Hydrophobic drug inclusion; DRUG-DELIVERY; OXIDE NANOPARTICLES; INCLUSION COMPLEXES; CARRIER SYSTEMS; CANCER-CELLS; NANOSPHERES; RESONANCE; PLATFORM; RELEASE; BINDING;

D O I：

10.1016/j.carbpol.2013.02.046

中图分类号：

O69 [应用化学];

学科分类号：

070301 [无机化学];

摘要：

We present synthesis of highly uniform magnetic nanocomposite material possessing an assortment of important functionalities: magnetism, luminescence, cell-targeting, and hydrophobic drug delivery. Magnetic particle Fe3O4 is encapsulated within a shell of SiO2 that ensures biocompatibility of the nanocomposite as well as act as a host for fluorescent dye (FITC), cancer-targeting ligand (folic acid), and a hydrophobic drug storage-delivering vehicle (beta-cyclodextrin). Our preliminary results suggest that such core-shell nanocomposite can be a smart theranostic candidate for simultaneous fluorescence imaging, magnetic manipulation, cancer cell-targeting and hydrophobic drug delivery. (c) 2013 Elsevier Ltd. All rights reserved.

引用

页码：449 / 457

页数：9

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