Synthesis of a novel magnetic drug delivery system composed of doxorubicin-conjugated Fe3O4 nanoparticle cores and a PEG-functionalized porous silica shell

被引：173

作者：

Chen, Feng-Hua ^{[1
]}

Zhang, Li-Ming ^{[1
]}

Chen, Qing-Tao ^{[1
]}

Zhang, Yi ^{[1
]}

Zhang, Zhi-Jun ^{[1
]}

机构：

[1] Chinese Acad Sci, Suzhou Inst Nanotech & Nanobion, Suzhou 215125, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2010年 / 46卷 / 45期

基金：

中国博士后科学基金; 中国国家自然科学基金;

关键词：

POROSITY; RELEASE; CELLS;

D O I：

10.1039/c0cc02577a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Coating a layer of PEG functionalized porous silica shell onto doxorubicin-conjugated Fe3O4 nanoparticles, we demonstrated, provides a number of combined advantages in view of the magnetic carrier's therapeutic functionality to treat tumors.

引用

页码：8633 / 8635

页数：3

共 17 条

[1] Drug release from self-assembled inorganic-organic hybrid gels and gated porosity detected by positron annihilation lifetime spectroscopy [J].

Bögershausen, A ;

Pas, SJ ;

Hill, AJ ;

Koller, H .

CHEMISTRY OF MATERIALS, 2006, 18 (03) :664-672

[2] The grafting and release behavior of doxorubincin from Fe3O4@SiO2 core-shell structure nanoparticles via an acid cleaving amide bond:: the potential for magnetic targeting drug delivery [J].

Chen, F. H. ;

Gao, Q. ;

Ni, J. Z. .

NANOTECHNOLOGY, 2008, 19 (16)

[3] Multifunctional magnetic nanoparticles for medical imaging applications [J].

Fang, Chen ;

Zhang, Miqin .

JOURNAL OF MATERIALS CHEMISTRY, 2009, 19 (35) :6258-6266

[4] Cancer nanotechnology: Opportunities and challenges [J].

Ferrari, M .

NATURE REVIEWS CANCER, 2005, 5 (03) :161-171

[5] Stimuli-responsive controlled-release delivery system based on mesoporous silica nanorods capped with magnetic nanoparticles [J].

Giri, S ;

Trewyn, BG ;

Stellmaker, MP ;

Lin, VSY .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2005, 44 (32) :5038-5044

[6] Nanoscaling laws of magnetic nanoparticles and their applicabilities in biomedical sciences [J].

Jun, Young-Wook ;

Seo, Jung-Wook ;

Cheon, Anw .

ACCOUNTS OF CHEMICAL RESEARCH, 2008, 41 (02) :179-189

[7] Methotrexate-immobilized poly(ethylene glycol) magnetic nanoparticles for MR imaging and drug delivery [J].

Kohler, N ;

Sun, C ;

Fichtenholtz, A ;

Gunn, J ;

Fang, C ;

Zhang, MQ .

SMALL, 2006, 2 (06) :785-792

[8] Methotrexate-modified superparamagnetic nanoparticles and their intracellular uptake into human cancer cells [J].

Kohler, N ;

Sun, C ;

Wang, J ;

Zhang, MQ .

LANGMUIR, 2005, 21 (19) :8858-8864

[9] Precise tuning of porosity and surface functionality in Au@SiO2 nanoreactors for high catalytic efficiency [J].

Lee, Joongoo ;

Park, Ji Chan ;

Bang, Jung Up ;

Song, Hyunjoon .

CHEMISTRY OF MATERIALS, 2008, 20 (18) :5839-5844

[10] Modifying the surface properties of superparamagnetic iron oxide nanoparticles through a sol-gel approach [J].

Lu, Y ;

Yin, YD ;

Mayers, BT ;

Xia, YN .

NANO LETTERS, 2002, 2 (03) :183-186

← 1 2 →