Ultrasound evaluation of liver fibrosis: preliminary experience with acoustic structure quantification (ASQ) software

被引：79

作者：

Ricci, Paolo ^{[1
]}

Marigliano, Chiara ^{[1
]}

Cantisani, Vito ^{[1
]}

Porfiri, Andrea ^{[1
]}

Marcantonio, Andrea ^{[1
]}

Lodise, Pietro ^{[1
]}

D'Ambrosio, Ugo ^{[1
]}

Labbadia, Giancarlo ^{[2
]}

Maggini, Elena ^{[1
]}

Mancuso, Ester ^{[1
]}

Panzironi, Giovanna ^{[1
]}

Di Segni, Mattia ^{[1
]}

Furlan, Caterina ^{[3
]}

Masciangelo, Raffaele ^{[4
]}

Taliani, Gloria ^{[3
]}

机构：

[1] Univ Roma La Sapienza, Azienda Policlin Umberto 1, Dipartimento Sci Radiol Oncol & Anatomopatol, I-00161 Rome, Italy

[2] Univ Roma La Sapienza, Azienda Policlin Umberto 1, Dipartimento Med Interna & Special Med, I-00161 Rome, Italy

[3] Univ Roma La Sapienza, Azienda Policlin Umberto 1, Dipartimento Malattie Infett & Trop, I-00161 Rome, Italy

[4] Univ Roma La Sapienza, Azienda Policlin Umberto 1, Dipartimento Sanita Pubbl & Malattie Infett, I-00161 Rome, Italy

来源：

RADIOLOGIA MEDICA | 2013年 / 118卷 / 06期

关键词：

Acoustic structure quantification; Liver fibrosis; Fibroscan; TIME TISSUE ELASTOGRAPHY; CHRONIC HEPATITIS-C; TRANSIENT ELASTOGRAPHY; NONINVASIVE ASSESSMENT; DISEASE; BIOPSY;

D O I：

10.1007/s11547-013-0940-0

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

100231 [临床病理学]; 100902 [航空航天医学];

摘要：

The aim of our study was to assess the diagnostic accuracy of acoustic structure quantification (ASQ) ultrasound software in estimating the degree of hepatic fibrosis compared to Fibroscan and liver biopsy. Seventy-seven patients with chronic viral hepatitis B and C underwent standard ultrasound examination, ASQ, Fibroscan and liver biopsy. ASQ analysis was conducted by placing a single region of interest (ROI) on each image captured, and calculating mode, average and standard deviation. The sonographic technique was developed through a preliminary evaluation of 20 healthy volunteers. The area under the receiver operating characteristic (AUROC) curve for the diagnosis of cirrhosis (Fa parts per thousand yen4) with ASQ was 0.77, whereas for the diagnosis of any degree of fibrosis (Fa parts per thousand yen1) it was 0.71. The AUROC for the diagnosis of cirrhosis (Fa parts per thousand yen4) with Fibroscan was 0.98, while for the diagnosis of any degree of fibrosis (Fa parts per thousand yen1) it was 0.94. The difference between the AUROC was statistically significant (p < 0.05). ASQ is a promising new ultrasound software programme which offers encouraging results in the diagnosis of both liver cirrhosis (F=4) and fibrosis (Fa parts per thousand yen1). However, to date it has not attained the same level of diagnostic performance as Fibroscan.

引用

页码：995 / 1010

页数：16

共 17 条

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Viscoelasticity-based Staging of Hepatic Fibrosis with Multifrequency MR Elastography [J].