N-Acyl-2-benzoxazolinones in titanium-mediated Aldol reactions

被引：10

作者：

Burlingame, MA ^{[1
]}

Mendoza, E ^{[1
]}

Ashley, GW ^{[1
]}

机构：

[1] Kosan Biosci Inc, Dept Chem, Hayward, CA 94545 USA

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 14期

关键词：

D O I：

10.1016/j.tetlet.2004.02.029

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

N-Acyl-2-benzoxazolinones readily form trichlorotitanium enolates that react rapidly with aldehydes to provide crystalline syn-aldol adducts in high yield. The resulting products are simply converted to amides, esters, and thioesters. A simple, economical synthesis of 3-hydroxy-2-methylpentanoate N-propionylcysteamine thioesters based on these findings is presented. (C) 2004 Elsevier Ltd. All rights reserved.

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页码：2961 / 2964

页数：4

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