A new immunosuppressive cyclic nonapeptide, cyclolinopeptide B from Linum usitatissimum

被引：45

作者：

Morita, H ^{[1
]}

Shishido, A ^{[1
]}

Matsumoto, T ^{[1
]}

Takeya, K ^{[1
]}

Itokawa, H ^{[1
]}

Hirano, T ^{[1
]}

Oka, K ^{[1
]}

机构：

[1] TOKYO UNIV PHARM & LIFE SCI,SCH PHARM,HACHIOJI,TOKYO 19203,JAPAN

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 10期

关键词：

D O I：

10.1016/S0960-894X(97)00206-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new cyclic nonapeptide, cyclolinopeptide B: cyclo (-Pro-Pro-Phe-Phe-Val-Ile-Met-Leu-Ile-), has been isolated from the seeds of Linum usitatissimum and its structure was elucidated by extensive 2D NMR methods and chemical degradations. Cyclolinopeptide B showed potent immunosuppressive activity comparable with that of cyclosporin A. (C) 1997 Elsevier Science Ltd.

引用

页码：1269 / 1272

页数：4

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