NEW ANTITUMOR BICYCLIC HEXAPEPTIDES, RA-IX AND RA-X FROM RUBIA-CORDIFOLIA .3. CONFORMATION ANTITUMOR-ACTIVITY RELATIONSHIP

被引：50

作者：

ITOKAWA, H

YAMAMIYA, T

MORITA, H

TAKEYA, K

机构：

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1992年 / 04期

关键词：

D O I：

10.1039/p19920000455

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

RA-IX and -X, new antitumour bicyclic hexapeptides were isolated from Rubia cordifolia and their structures were elucidated by spectroscopic and chemical evidences. RA-X containing a glutamic acid at residue 2 showed strong antitumour activity. However, RA-IX with conformation restricted to a type II beta-turn at residues 2 and 3 showed almost no antitumour activity. Their conformation-antitumour activity relationships are discussed.

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页码：455 / 459

页数：5

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