Bat cells from Pteropus alecto are susceptible to influenza A virus infection and reassortment

被引：19

作者：

Dlugolenski, Daniel ^{[1
]}

Jones, Les ^{[1
]}

Tompkins, S. Mark ^{[1
]}

Crameri, Gary ^{[2
]}

Wang, Lin-Fa ^{[2
,3
]}

Tripp, Ralph A. ^{[1
]}

机构：

[1] Univ Georgia, Dept Infect Dis, Coll Vet Med, Athens, GA 30602 USA

[2] CSIRO Australian Anim Hlth Lab, Geelong, Vic, Australia

[3] Duke NUS Grad Med Sch, Singapore, Singapore

来源：

INFLUENZA AND OTHER RESPIRATORY VIRUSES | 2013年 / 7卷 / 06期

基金：

美国国家卫生研究院;

关键词：

Bats; H1N1; H5N1; influenza; reassortment; SWINE;

D O I：

10.1111/irv.12128

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Waterfowl are primary hosts for influenza A viruses (IAVs); however, there is sporadic infection of swine and other species that pose a risk of zoonotic spread. Yellow-shouldered bats were shown to be hosts of an IAV, thereby constituting a potential novel reservoir. We show that Pteropus alecto kidney cells (PaKi) are susceptible to infection and sustain replication of A/WSN/33 (H1N1) and A/Vietnam/1203/04 (H5N1). Importantly, we show that co-infection of PaKi cells results in novel reassortants.

引用

页码：900 / 903

页数：4

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