High-grade glioma before and after treatment with radiation and Avastin: Initial observations

被引：63

作者：

Fischer, Ingeborg ^{[1
]}

Cunliffe, Clare H. ^{[1
]}

Bollo, Robert J. ^{[2
]}

Raza, Shahzad ^{[5
]}

Monoky, David ^{[3
]}

Chiriboga, Luis ^{[1
]}

Parker, Erik C. ^{[2
]}

Golfinos, John G. ^{[2
]}

Kelly, Patrick J. ^{[2
]}

Knopp, Edmond A. ^{[3
]}

Gruber, Michael L. ^{[4
]}

Zagzag, David ^{[1
]}

Narayana, Ashwatha ^{[5
]}

机构：

[1] NYU, Med Ctr, Dept Pathol, New York, NY 10016 USA

[2] NYU, Med Ctr, Dept Neurosurg, New York, NY 10016 USA

[3] NYU, Med Ctr, Dept Radiol, New York, NY 10016 USA

[4] NYU, Med Ctr, Dept Oncol, New York, NY 10016 USA

[5] NYU, Med Ctr, Dept Radiat Oncol, New York, NY 10016 USA

来源：

NEURO-ONCOLOGY | 2008年 / 10卷 / 05期

关键词：

angiogenesis; Avastin; bevacizumab; biomarkers; glioblastoma; glioma;

D O I：

10.1215/15228517-2008-042

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We evaluate the effects of adjuvant treatment with the angiogenesis inhibitor Avastin (bevacizumab) on pathological tissue specimens of high-grade glioma. Tissue from five patients before and after treatment with Avastin was subjected to histological evaluation and compared to four control cases of glioma before and after similar treatment protocols not including bevacizumab. Clinical and radiographic data were reviewed. Histological analysis focused on microvessel density and vascular morphology, and expression patterns of vascular endothelial growth factor-A (VEGF-A) and the hematopoietic stem cell, mesenchymal, and cell motility markers CD34, smooth muscle actin, D2-40, and fascin. All patients with a decrease in microvessel density had a radiographic response, whereas no response was seen in the patients with increased microvessel density. Vascular morphology showed apparent "normalization" after Avastin treatment in two cases, with thin-walled and evenly distributed vessels. VEGF-A expression in tumor cells was increased in two cases and decreased in three and did not correlate with treatment response. There was a trend toward a relative increase of CD34, smooth muscle actin, D2-40, and fascin immunostaining following treatment with Avastin. Specimens from four patients with recurrent malignant gliomas before and after adjuvant treatment (not including bevacizumab) had features dissimilar from our study cases. We conclude that a change in vascular morphology can be observed following antiangiogenic treatment. There seems to be no correlation between VEGF-A expression and clinical parameters. While the phenomena we describe may not be specific to Avastin, they demonstrate the potential of tissue-based analysis for the discovery of clinically relevant treatment response biomarkers. Neuro-Oncology 10, 700-708, 2008 (Posted to Neuro-Oncology [serial online], Doc. D08-00-006, August 12, 2008. URL http:neuro-oncology.dukejournals.org; DOI: 10.1215/15228517-2008-042)

引用

页码：700 / 708

页数：9

共 39 条

[1] Roles of fascin in cell adhesion and motility [J].