Cancer metabolism: fatty acid oxidation in the limelight

被引：1014

作者：

Carracedo, Arkaitz ^{[1
,2
,3
]}

Cantley, Lewis C. ^{[4
,5
]}

Pandolfi, Pier Paolo ^{[6
,7
]}

机构：

[1] CIC bioGUNE, Derio, Spain

[2] Basque Fdn Sci, IKERBASQUE, Bilbao 48160, Spain

[3] Univ Basque Country UPV EHU, Dept Biochem & Mol Biol, E-48080 Bilbao, Spain

[4] Beth Israel Deaconess Med Ctr, Dept Med, Div Signal Transduct, Boston, MA 02215 USA

[5] Harvard Univ, Sch Med, Dept Syst Biol, Boston, MA 02115 USA

[6] Beth Israel Deaconess Canc Ctr, Canc Genet Program, Boston, MA 02215 USA

[7] Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Dept Pathol & Med, Boston, MA 02215 USA

来源：

NATURE REVIEWS CANCER | 2013年 / 13卷 / 04期

基金：

美国国家卫生研究院;

关键词：

CELL-SURVIVAL; ENERGY; INHIBITION; GLYCOLYSIS; PATHWAY; PROTEIN; STRESS; GROWTH; CPT1C; FLUX;

D O I：

10.1038/nrc3483

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Warburg suggested that the alterations in metabolism that he observed in cancer cells were due to the malfunction of mitochondria. In the past decade, we have revisited this idea and reached a better understanding of the 'metabolic switch' in cancer cells, including the intimate and causal relationship between cancer genes and metabolic alterations, and their potential to be targeted for cancer treatment. However, the vast majority of the research into cancer metabolism has been limited to a handful of metabolic pathways, while other pathways have remained in the dark. This Progress article brings to light the important contribution of fatty acid oxidation to cancer cell function.

引用

页码：227 / 232

页数：6

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