Surveillance of the Middle East respiratory syndrome (MERS) coronavirus (CoV) infection in healthcare workers after contact with confirmed MERS patients: incidence and risk factors of MERS-CoV seropositivity

被引：43

作者：

Kim, C-J. ^{[1
]}

Choi, W. S. ^{[2
]}

Jung, Y. ^{[3
]}

Kiem, S. ^{[4
]}

Seol, H. Y. ^{[5
]}

Woo, H. J. ^{[6
]}

Choi, Y. H. ^{[7
]}

Son, J. S. ^{[8
]}

Kim, K-H. ^{[9
]}

Kim, Y-S. ^{[10
]}

Kim, E. S. ^{[11
]}

Park, S. H. ^{[12
]}

Yoon, J. H. ^{[13
]}

Choi, S-M. ^{[14
]}

Lee, H. ^{[15
]}

Oh, W. S. ^{[16
]}

Choi, S-Y. ^{[17
]}

Kim, N-J. ^{[18
]}

Choi, J-P. ^{[19
]}

Park, S. Y. ^{[20
]}

Kim, J. ^{[21
]}

Jeong, S. J. ^{[22
]}

Lee, K. S. ^{[23
]}

Jang, H. C. ^{[24
]}

Rhee, J. Y. ^{[25
]}

Kim, B-N. ^{[26
]}

Bang, J. H. ^{[27
]}

Lee, J. H. ^{[28
]}

Park, S. ^{[29
]}

Kim, H. Y. ^{[30
]}

Choi, J. K. ^{[31
]}

Wi, Y-M. ^{[32
]}

Choi, H. J. ^{[1
]}

机构：

[1] Ewha Womans Univ, Sch Med, Dept Internal Med, Div Infect Dis, 1071 Anyangcheon Ro, Seoul, South Korea

[2] Korea Univ, Div Infect Dis, Dept Internal Med, Coll Med, Seoul, South Korea

[3] Konyang Univ Hosp, Dept Internal Med, Nonsan, South Korea

[4] Inje Univ, Haeundae Paik Hosp, Dept Internal Med, Gimhae, South Korea

[5] Good GangAn Hosp, Dept Internal Med, Busan, South Korea

[6] Hallym Univ, Dongtan Sacred Heart Hosp, Dept Internal Med, Chunchon, South Korea

[7] Ajou Univ Hosp, Dept Internal Med, Suwon, South Korea

[8] Kyung Hee Univ, Hosp Gangdong, Dept Internal Med, Seoul, South Korea

[9] Pusan Natl Univ Hosp, Dept Internal Med, Busan, South Korea

[10] Chungnam Natl Univ, Sch Med, Dept Internal Med, Div Infect Dis, Daejeon, South Korea

[11] Seoul Natl Univ, Bundang Hosp, Dept Internal Med, Seoul, South Korea

[12] Catholic Univ Korea, Daejeon St Marys Hosp, Coll Med, Dept Internal Med, Seoul, South Korea

[13] Eulji Univ Hosp, Dept Internal Med, Daejeon, South Korea

[14] Catholic Univ Korea, Yeouido St Marys Hosp, Coll Med, Dept Internal Med, Seoul, South Korea

[15] Dong A Univ Hosp, Div Infect Dis, Busan, South Korea

[16] Kangwon Natl Univ Hosp, Dept Internal Med, Chunchon, South Korea

[17] Dae Cheong Hosp, Dept Neurol, Daejeon, South Korea

[18] Seoul Natl Univ Hosp, Dept Internal Med, Seoul, South Korea

[19] Seoul Med Ctr, Dept Internal Med, Seoul, South Korea

[20] Hallym Univ, Kangdong Sacred Heart Hosp, Dept Internal Med, Chunchon, South Korea

[21] Hanyang Univ, Guri Hosp, Dept Internal Med, Seoul, South Korea

[22] Gangnam Severance Hosp, Dept Internal Med, Seoul, South Korea

[23] Myongji Hosp, Dept Internal Med, Seoul, South Korea

[24] Chonnam Natl Univ Hosp, Dept Internal Med, Gwangju, South Korea

[25] Dankook Univ Hosp, Dept Internal Med, Cheonan Si, South Korea

[26] Inje Univ, Sanggye Paik Hosp, Dept Internal Med, Gimhae, South Korea

[27] Borame Med Ctr, Dept Internal Med, Gimhae, South Korea

[28] Wonkwang Univ Hosp, Dept Internal Med, Iksan, South Korea

[29] Seobuk Hosp Seoul Metropolitan Govt, Dept Family Med, Seoul, South Korea

[30] Wonju Severance Christian Hosp, Dept Internal Med, Wonju, South Korea

[31] Catholic Univ Korea, Bucheon St Marys Hosp, Coll Med, Dept Internal Med, Seoul, South Korea

[32] Samsung Changwon Hosp, Dept Internal Med, Seoul, South Korea

来源：

CLINICAL MICROBIOLOGY AND INFECTION | 2016年 / 22卷 / 10期

关键词：

Healthcare personnel; IgG; Incidence; Middle East respiratory syndrome; Personal protective equipment; UNITED-STATES; SAUDI-ARABIA; OUTBREAK; TRANSMISSION; ANTIBODIES; SETTINGS;

D O I：

10.1016/j.cmi.2016.07.017

中图分类号：

R51 [传染病];

学科分类号：

100201 [内科学];

摘要：

Given the mode of transmission of Middle East respiratory syndrome (MERS), healthcare workers (HCWs) in contact with MERS patients are expected to be at risk of MERS infections. We evaluated the prevalence of MERS coronavirus (CoV) immunoglobulin (Ig) G in HCWs exposed to MERS patients and calculated the incidence of MERS-affected cases in HCWs. We enrolled HCWs from hospitals where confirmed MERS patients had visited. Serum was collected 4 to 6 weeks after the last contact with a confirmed MERS patient. We performed an enzyme-linked immunosorbent assay (ELISA) to screen for the presence of MERS-CoV IgG and an indirect immunofluorescence test (IIFT) to confirm MERS-CoV IgG. We used a questionnaire to collect information regarding the exposure. We calculated the incidence of MERS-affected cases by dividing the sum of PCR-confirmed and serology-confirmed cases by the number of exposed HCWs in participating hospitals. In total, 1169 HCWs in 31 hospitals had contact with 114 MERS patients, and among the HCWs, 15 were PCR-confirmed MERS cases in study hospitals. Serologic analysis was performed for 737 participants. ELISA was positive in five participants and borderline for seven. IIFT was positive for two (0.3%) of these 12 participants. Among the participants who did not use appropriate personal protective equipment (PPE), seropositivity was 0.7% (2 / 294) compared to 0% (0 / 443) in cases with appropriate PPE use. The incidence of MERS infection in HCWs was 1.5% (17 / 1169). The seroprevalence of MERS-CoV IgG among HCWs was higher among participants who did not use appropriate PPE. (C) 2016 Published by Elsevier Ltd on behalf of European Society of Clinical Microbiology and Infectious Diseases.

引用

页码：880 / 886

页数：7

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