IL-17 family cytokines mediated signaling in the pathogenesis of inflammatory diseases

被引：259

作者：

Song, Xinyang ^{[1
]}

Qian, Youcun ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Chinese Acad Sci, Sch Med, Key Lab Stem Cell Biol,Inst Hlth Sci,Shanghai Ins, Shanghai 200025, Peoples R China

来源：

CELLULAR SIGNALLING | 2013年 / 25卷 / 12期

基金：

中国国家自然科学基金;

关键词：

IL-17 family cytokines; Signal transduction; Inflammation; GENOME-WIDE ASSOCIATION; TH17; CELL-DIFFERENTIATION; ROR-GAMMA-T; COLLAGEN-INDUCED ARTHRITIS; GROWTH-FACTOR-BETA; MESSENGER-RNA; CUTTING EDGE; HOST-DEFENSE; AIRWAY HYPERRESPONSIVENESS; IL-17-PRODUCING CELLS;

D O I：

10.1016/j.cellsig.2013.07.021

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Inflammation is the immediate protective response of the body to pathogen invasions, allergen challenges, chemical exposures or physical injuries. Acute inflammation usually accompanies with transient infiltration of leukocytes, removal of danger signals and eventually tissue repair, while persistent and uncontrolled inflammation becomes a major stimulator in the progression of many chronic diseases in human, including autoimmune diseases, metabolic disorders and cancer. Interleukin (IL)-17 family is a recent classified subset of cytokines, playing critical roles in both acute and chronic inflammatory responses. In this review, we will summarize recent progresses on the signalings of this family cytokines and their impacts on the inflammatory responses or disorders. (C) 2013 Elsevier Inc. All rights reserved.

引用

页码：2335 / 2347

页数：13

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