Novel applications of ethyl glyoxalate with the Ugi MCR

被引：117

作者：

Hulme, C ^{[1
]}

Cherrier, MP ^{[1
]}

机构：

[1] Rhone Poulenc Rorer Cent Res, Lead Discovery, Collegeville, PA 19426 USA

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 29期

关键词：

D O I：

10.1016/S0040-4039(99)00960-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

This letter describes novel high-yielding solution phase preparations of 1,4-benzodiazepine-2,5-dione, diketopiperazine, ketopiperazine and dihydroquinoxalinone libraries via a UDC (Ugi/de-Boc/cyclization) strategy in combination with ethylglyoxalate. The methodology represents a 'three step, one-pot procedure', employing the Ugi multi-component reaction (MCR), followed by Boc deprotection and cyclization. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：5295 / 5299

页数：5

共 26 条

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