Chromosome segregation: Dual control ensures fidelity

被引：34

作者：

Taylor, SS ^{[1
]}

机构：

[1] Univ Manchester, Sch Biol Sci, Manchester M13 9PT, Lancs, England

来源：

CURRENT BIOLOGY | 1999年 / 9卷 / 15期

关键词：

D O I：

10.1016/S0960-9822(99)80355-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A mitotic checkpoint arrests cell cycle progression in response to spindle damage. It now appears that this checkpoint has two separate arms, one that prevents anaphase and a second that prevents cytokinesis and DNA re-replication.

引用

页码：R562 / R564

页数：3

共 22 条

[1] Sister chromatid separation and chromosome re-duplication are regulated by different mechanisms in response to spindle damage [J].

Alexandru, G ;

Zachariae, W ;

Schleiffer, A ;

Nasmyth, K .

EMBO JOURNAL, 1999, 18 (10) :2707-2721

[2]

Cerutti L, 1999, J CELL SCI, V112, P2313

[3] Bub1p kinase activates the Saccharomyces cerevisiae spindle assembly checkpoint [J].

Farr, KA ;

Hoyt, MA .

MOLECULAR AND CELLULAR BIOLOGY, 1998, 18 (05) :2738-2747

[4] A Bub2p-dependent spindle checkpoint pathway regulates the Dbf2p kinase in budding yeast [J].

Fesquet, D ;

Fitzpatrick, PJ ;

Johnson, AL ;

Kramer, KM ;

Toyn, JH ;

Johnston, LH .

EMBO JOURNAL, 1999, 18 (09) :2424-2434

[5] Budding yeast Bub2 is localized at spindle pole bodies and activates the mitotic checkpoint via a different pathway from Mad2 [J].

Fraschini, R ;

Formenti, E ;

Lucchini, G ;

Piatti, S .

JOURNAL OF CELL BIOLOGY, 1999, 145 (05) :979-991

[6] Byr4 and Cdc16 form a two-component GTPase-activating protein for the Spg1 GTPase that controls septation in fission yeast [J].

Furge, KA ;

Wong, K ;

Armstrong, J ;

Balasubramanian, M ;

Albright, CF .

CURRENT BIOLOGY, 1998, 8 (17) :947-954

[7] Microinjection of antibody to Mad2 protein into mammalian cells in mitosis induces premature anaphase [J].

Gorbsky, GJ ;

Chen, RH ;

Murray, AW .

JOURNAL OF CELL BIOLOGY, 1998, 141 (05) :1193-1205

[8] The spindle checkpoint [J].

Hardwick, KG .

TRENDS IN GENETICS, 1998, 14 (01) :1-4

[9] Activation of the budding yeast spindle assembly checkpoint without mitotic spindle disruption [J].

Hardwick, KG ;

Weiss, E ;

Luca, FC ;

Winey, M ;

Murray, AW .

SCIENCE, 1996, 273 (5277) :953-956

[10] A late mitotic regulatory network controlling cyclin destruction in Saccharomyces cerevisiae [J].

Jaspersen, SL ;

Charles, JF ;

Tinker-Kulberg, RL ;

Morgan, DO .

MOLECULAR BIOLOGY OF THE CELL, 1998, 9 (10) :2803-2817

← 1 2 3 →