Synthesis of texaphyrin conjugates

被引:16
作者
Magda, DJ
Wang, Z
Gerasimchuk, N
Wei, WH
Anzenbacher, P
Sessler, JL
机构
[1] Univ Texas, Dept Chem & Biochem, Austin, TX 78712 USA
[2] Pharmacycl Inc, Sunnyvale, CA 94085 USA
关键词
D O I
10.1351/pac200476020365
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
This paper summarizes recent synthetic efforts devoted to the generation of new, second-generation texaphyrin-type drugs, specifically species that involve known or potential anticancer agents covalently attached to a tumor-localizing texaphyrin core. Particular emphasis will be placed on the strategies needed to prepare such systems, as well as on the choice of active group being subject to attachment.
引用
收藏
页码:365 / 374
页数:10
相关论文
共 45 条
  • [21] Redox cycling by motexafin gadolinium enhances cellular response to ionizing radiation by forming reactive oxygen species
    Magda, D
    Lepp, C
    Gerasimchuk, N
    Lee, I
    Sessler, JL
    Lin, A
    Biaglow, JE
    Miller, RA
    [J]. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2001, 51 (04): : 1025 - 1036
  • [22] MAGDA D, 2003, AM SOC CLIN ONCOL P, V22, P229
  • [23] RADIOSENSITIZATION BY MISONIDAZOLE DURING RECOVERY OF CELLULAR THIOLS FOLLOWING DEPLETION BY BSO OR DEM
    MCNALLY, NJ
    SORANSON, JA
    [J]. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1989, 16 (05): : 1331 - 1334
  • [24] Lead-in phase to randomized trial of motexafin gadolinium and whole-brain radiation for patients with brain metastases: Centralized assessment of magnetic resonance imaging, neurocognitive, and neurologic end points
    Mehta, MP
    Shapiro, WR
    Glantz, MJ
    Patchell, RA
    Weitzner, MA
    Meyers, CA
    Schultz, CJ
    Roa, WH
    Leibenhaut, M
    Ford, J
    Curran, W
    Phan, S
    Smith, JA
    Miller, RA
    Renschler, MF
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2002, 20 (16) : 3445 - 3453
  • [25] Survival and neurologic outcomes in a randomized trial of motexafin gadolinium and whole-brain radiation therapy in brain metastases
    Mehta, MP
    Rodrigus, P
    Terhaard, CHJ
    Rao, A
    Suh, J
    Roa, W
    Soukami, L
    Bezjak, A
    Leibenhaut, M
    Komaki, R
    Schultz, C
    Timmerman, R
    Curran, W
    Smith, J
    Phan, SC
    Miller, RA
    Renschler, MF
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2003, 21 (13) : 2529 - 2536
  • [26] MITOCHONDRIAL CHANGES ASSOCIATED WITH GLUTATHIONE DEFICIENCY
    MEISTER, A
    [J]. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 1995, 1271 (01): : 35 - 42
  • [27] The p66shc adaptor protein controls oxidative stress response and life span in mammals
    Migliaccio, E
    Giorgio, M
    Mele, S
    Pelicci, G
    Reboidl, P
    Pandolfi, PP
    Lanfrancone, L
    Pelicci, PG
    [J]. NATURE, 1999, 402 (6759) : 309 - 313
  • [28] Miller RA, 2001, CLIN CANCER RES, V7, P3215
  • [29] In vivo animal studies with gadolinium (III) texaphyrin as a radiation enhancer
    Miller, RA
    Woodburn, K
    Fan, Q
    Renschler, MF
    Sessler, JL
    Koutcher, JA
    [J]. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1999, 45 (04): : 981 - 989
  • [30] SECONDARY ALCOHOL METABOLITES MEDIATE IRON DELOCALIZATION IN CYTOSOLIC FRACTIONS OF MYOCARDIAL BIOPSIES EXPOSED TO ANTICANCER ANTHRACYCLINES - NOVEL LINKAGE BETWEEN ANTHRACYCLINE METABOLISM AND IRON-INDUCED CARDIOTOXICITY
    MINOTTI, G
    CAVALIERE, AF
    MORDENTE, A
    ROSSI, M
    SCHIAVELLO, R
    ZAMPARELLI, R
    POSSATI, G
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1995, 95 (04) : 1595 - 1605