Hsa-miR-125b suppresses bladder cancer development by down-regulating oncogene SIRT7 and oncogenic long non-coding RNA MALAT1

被引：188

作者：

Han, Yonghua ^{[1
]}

Liu, Yuchen ^{[1
]}

Zhang, Hu ^{[2
]}

Wang, Tiantian ^{[2
]}

Diao, Ruiying ^{[1
]}

Jiang, Zhimao ^{[2
]}

Gui, Yaoting ^{[2
]}

Cai, Zhiming ^{[1
]}

机构：

[1] Sun Yat Sen Univ, Shenzhen Peoples Hosp 2, Postdoctoral Sci Res Base, Shenzhen Key Lab Genitourinary Tumor,Zhongshan Sc, Shenzhen, Peoples R China

[2] Peking Univ, Shenzhen Hosp, Guangdong Key Lab Male Reprod Med & Genet, Shenzhen 518036, Peoples R China

来源：

FEBS LETTERS | 2013年 / 587卷 / 23期

基金：

中国博士后科学基金; 中国国家自然科学基金;

关键词：

Bladder cancer; MicroRNA; Hsa-miR-125b; SIRT7; Long non-coding RNA; MALAT1; MICRORNAS; EXPRESSION; INVASION;

D O I：

10.1016/j.febslet.2013.10.023

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

MicroRNAs mainly inhibit coding genes and long non-coding RNA expression. Here, we report that hsa-miR-125b and oncogene SIRT7/oncogenic long non-coding RNA MALAT1 were inversely expressed in bladder cancer. Hsa-miR-125b mimic down-regulated, whereas hsa-miR-125b inhibitor up-regulated the expression of SIRT7 and MALAT1. Binding sites were confirmed between hsamiR- 125b and SIRT7/MALAT1. Up-regulation of hsa-miR-125b or down-regulation of SIRT7 inhibited proliferation, motility and increased apoptosis. The effects of up-regulation of hsa-miR-125b were similar to that of silencing MALAT1 in bladder cancer as we had previously described. These data suggest that hsa-miR-125b suppresses bladder cancer development via inhibiting SIRT7 and MALAT1. (C) 2013 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.

引用

页码：3875 / 3882

页数：8

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