Parasites and immunoregulatory T cells

被引:42
作者
Belkaid, Yasmine [1 ]
Sun, Cheng Ming [1 ]
Bouladoux, Nicolas [1 ]
机构
[1] NIAID, Mucosal Immunol Unit, Parasit Dis Lab, NIH, Bethesda, MD 20892 USA
关键词
D O I
10.1016/j.coi.2006.05.014
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Surviving a parasitic infection requires the generation of a controlled immune response. Failure to establish or to maintain homeostatic conditions usually causes disease. Investigation of the immunoregulatory network as the response to the parasitic process or induced by the parasite promises enormous therapeutic benefits for the control of parasitic diseases. Recent findings implicate various populations of regulatory T cells in this homeostatic regulation.
引用
收藏
页码:406 / 412
页数:7
相关论文
共 75 条
[1]   PERSISTENCE OF VIRULENT LEISHMANIA-MAJOR IN MURINE CUTANEOUS LEISHMANIASIS - A POSSIBLE HAZARD FOR THE HOST [J].
AEBISCHER, T ;
MOODY, SF ;
HANDMAN, E .
INFECTION AND IMMUNITY, 1993, 61 (01) :220-226
[2]   Nonhealing infection despite Th1 polarization produced by a strain of Leishmania major in C57BL/6 mice [J].
Anderson, CF ;
Mendez, S ;
Sacks, DL .
JOURNAL OF IMMUNOLOGY, 2005, 174 (05) :2934-2941
[3]   The IL-27 receptor (WSX-1) is an inhibitor of innate and adaptive elements of type 2 immunity [J].
Artis, D ;
Villarino, A ;
Silverman, M ;
He, WM ;
Thornton, EM ;
Mu, S ;
Summer, S ;
Covey, TM ;
Huang, E ;
Yoshida, H ;
Koretzky, G ;
Goldschmidt, M ;
Wu, GD ;
de Sauvage, F ;
Miller, HRP ;
Saris, CJM ;
Scott, P ;
Hunter, CA .
JOURNAL OF IMMUNOLOGY, 2004, 173 (09) :5626-5634
[4]   The early IL-4 response to Leishmania major and the resulting Th2 cell maturation steering progressive disease in BALB/c mice are subject to the control of regulatory CD4+CD25+ T cells [J].
Aseffa, A ;
Gumy, A ;
Launois, P ;
MacDonald, HR ;
Louis, JA ;
Tacchini-Cottier, F .
JOURNAL OF IMMUNOLOGY, 2002, 169 (06) :3232-3241
[5]   CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity [J].
Belkaid, Y ;
Piccirillo, CA ;
Mendez, S ;
Shevach, EM ;
Sacks, DL .
NATURE, 2002, 420 (6915) :502-507
[6]   The role of interleukin (IL)-10 in the persistence of Leishmania major in the skin after healing and the therapeutic potential of anti-IL-10 receptor antibody for sterile cure [J].
Belkaid, Y ;
Hoffmann, KF ;
Mendez, S ;
Kamhawi, S ;
Udey, MC ;
Wynn, TA ;
Sacks, DL .
JOURNAL OF EXPERIMENTAL MEDICINE, 2001, 194 (10) :1497-1506
[7]   An immunomodulatory role for CD4+CD25+ regulatory T lymphocytes in hepatitis C virus infection [J].
Cabrera, R ;
Tu, ZK ;
Xu, YL ;
Firpi, RJ ;
Rosen, HR ;
Liu, C ;
Nelson, DR .
HEPATOLOGY, 2004, 40 (05) :1062-1071
[8]   Activation of toll-like receptor-2 by glycosylphosphatidylinositol anchors from a protozoan parasite [J].
Campos, MA ;
Almeida, IC ;
Takeuchi, O ;
Akira, S ;
Valente, EP ;
Procópio, DO ;
Travassos, LR ;
Smith, JA ;
Golenbock, DT ;
Gazzinelli, RT .
JOURNAL OF IMMUNOLOGY, 2001, 167 (01) :416-423
[9]   Regulatory T cells selectively express toll-like receptors and are activated by lipopolysaccharide [J].
Caramalho, I ;
Lopes-Carvalho, T ;
Ostler, D ;
Zelenay, S ;
Haury, M ;
Demengeot, J .
JOURNAL OF EXPERIMENTAL MEDICINE, 2003, 197 (04) :403-411
[10]  
CARVALHO EM, 1994, J IMMUNOL, V152, P5949