Parasites and immunoregulatory T cells

被引：42

作者：

Belkaid, Yasmine ^{[1
]}

Sun, Cheng Ming ^{[1
]}

Bouladoux, Nicolas ^{[1
]}

机构：

[1] NIAID, Mucosal Immunol Unit, Parasit Dis Lab, NIH, Bethesda, MD 20892 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2006年 / 18卷 / 04期

关键词：

D O I：

10.1016/j.coi.2006.05.014

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Surviving a parasitic infection requires the generation of a controlled immune response. Failure to establish or to maintain homeostatic conditions usually causes disease. Investigation of the immunoregulatory network as the response to the parasitic process or induced by the parasite promises enormous therapeutic benefits for the control of parasitic diseases. Recent findings implicate various populations of regulatory T cells in this homeostatic regulation.

引用

页码：406 / 412

页数：7

共 75 条

[51] Interleukin 10-mediated immunosuppression by a variant CD4 T cell epitope of Plasmodium falciparum [J].

Plebanski, M ;

Flanagan, KL ;

Lee, EAM ;

Reece, WHH ;

Hart, K ;

Gelder, C ;

Gillespie, G ;

Pinder, M ;

Hill, AVS .

IMMUNITY, 1999, 10 (06) :651-660

[52]

Powrie Fiona, 2003, Novartis Found Symp, V252, P92

[53] Evasion of innate immunity by parasitic protozoa [J].

Sacks, D ;

Sher, A .

NATURE IMMUNOLOGY, 2002, 3 (11) :1041-1047

[54] IL-10 is critical for host resistance and survival during gastrointestinal helminth infection [J].

Schopf, LR ;

Hoffmann, KF ;

Cheever, AW ;

Urban, JF ;

Wynn, TA .

JOURNAL OF IMMUNOLOGY, 2002, 168 (05) :2383-2392

[55] CD40 ligation releases immature dendritic cells from the control of regulatory CD4+CD25+ T cells [J].

Serra, P ;

Amrani, A ;

Yamanouchi, J ;

Han, BY ;

Thiessen, S ;

Utsugi, T ;

Verdaguer, J ;

Santamaria, P .

IMMUNITY, 2003, 19 (06) :877-889

[56] Retroviral Foxp3 gene transfer ameliorates liver granuloma pathology in Schistosoma mansoni infected mice [J].

Singh, KP ;

Gerard, HC ;

Hudson, AP ;

Reddy, TR ;

Boros, DL .

IMMUNOLOGY, 2005, 114 (03) :410-417

[57] IL-10 from regulatory T cells determines vaccine efficacy in murine Leishmania major infection [J].

Stober, CB ;

Lange, UG ;

Roberts, MTM ;

Alcami, A ;

Blackwell, JM .

JOURNAL OF IMMUNOLOGY, 2005, 175 (04) :2517-2524

[58] A role for CD103 in the retention of CD4+CD25+ Treg and control of Leishmania major infection [J].

Suffia, I ;

Reckling, SK ;

Salay, G ;

Belkaid, Y .

JOURNAL OF IMMUNOLOGY, 2005, 174 (09) :5444-5455

[59] Infected site-restricted Foxp3+ natural regulatory T cells are specific for microbial antigens [J].

Suffia, IJ ;

Reckling, SK ;

Piccirillo, CA ;

Goldszmid, RS ;

Belkaid, Y .

JOURNAL OF EXPERIMENTAL MEDICINE, 2006, 203 (03) :777-788

[60] Toll-like receptor 2 controls expansion and function of regulatory T cells [J].

Sutmuller, RPM ;

den Brok, MHMGM ;

Kramer, M ;

Bennink, EJ ;

Toonen, LWJ ;

Kullberg, BJ ;

Joosten, LA ;

Akira, S ;

Netea, MG ;

Adema, GJ .

JOURNAL OF CLINICAL INVESTIGATION, 2006, 116 (02) :485-494

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