Medulloblastomics: the end of the beginning

被引：481

作者：

Northcott, Paul A. ^{[13
]}

Jones, David T. W. ^{[13
]}

Kool, Marcel ^{[13
]}

Robinson, Giles W. ^{[11
,12
]}

Gilbertson, Richard J. ^{[11
,12
]}

Cho, Yoon-Jae ^{[10
]}

Pomeroy, Scott L. ^{[8
,9
]}

Korshunov, Andrey ^{[7
]}

Lichter, Peter ^{[6
]}

Taylor, Michael D. ^{[1
,2
,3
,4
]}

Pfister, Stefan M. ^{[5
]}

机构：

[1] Hosp Sick Children, Div Neurosurg, Dept Surg, Toronto, ON M5G 1X8, Canada

[2] Hosp Sick Children, Labatt Brain Tumour Res Ctr, Toronto, ON M5G 1X8, Canada

[3] Hosp Sick Children, Dev & Stem Cell Biol Program, Toronto, ON M5G 1L7, Canada

[4] Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON M5S 1A8, Canada

[5] Univ Heidelberg Hosp, Dept Pediat Oncol, D-69120 Heidelberg, Germany

[6] German Canc Res Ctr, Div Mol Genet, D-69120 Heidelberg, Germany

[7] German Canc Res Ctr, CCU Neuropathol, D-69120 Heidelberg, Germany

[8] Broad Inst Massachusetts Inst Technol & Harvard, Cambridge, MA 02142 USA

[9] Harvard Univ, Sch Med, Boston Childrens Hosp, Dept Neurol, Boston, MA 02115 USA

[10] Stanford Univ, Sch Med, Dept Neurol & Neurol Sci, Palo Alto, CA 94305 USA

[11] St Jude Childrens Res Hosp, Dept Dev Neurobiol, Memphis, TN 38105 USA

[12] St Jude Childrens Res Hosp, Dept Oncol, Memphis, TN 38105 USA

[13] German Canc Res Ctr, Div Pediat Neurooncol, D-69120 Heidelberg, Germany

来源：

NATURE REVIEWS CANCER | 2012年 / 12卷 / 12期

关键词：

HEDGEHOG PATHWAY INHIBITOR; TETRAPLOID TUMOR-CELLS; LEWY-BODY FORMATION; HUMAN HOMOLOG; BRAIN-TUMORS; BETA-CATENIN; WNT/WINGLESS PATHWAY; MOLECULAR SUBGROUPS; SMOOTHENED MUTATION; PROGNOSTIC-FACTORS;

D O I：

10.1038/nrc3410

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The division of medulloblastoma into different subgroups by microarray expression profiling has dramatically changed our perspective of this malignant childhood brain tumour. Now, the availability of next-generation sequencing and complementary high-density genomic technologies has unmasked novel driver mutations in each medulloblastoma subgroup. The implications of these findings for the management of patients are readily apparent, pinpointing previously unappreciated diagnostic and therapeutic targets. In this Review, we summarize the 'explosion' of data emerging from the application of modern genomics to medulloblastoma, and in particular the recurrent targets of mutation in medulloblastoma subgroups. These data are currently making their way into clinical trials as we seek to integrate conventional and molecularly targeted therapies.

引用

页码：818 / 834

页数：17

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