Sympathetic modulation of immunity: Relevance to disease

被引：176

作者：

Bellinger, Denise L. ^{[1
]}

Millar, Brooke A. ^{[1
]}

Perez, Sarn ^{[1
]}

Carter, Jeff ^{[1
]}

Wood, Carlo ^{[1
]}

ThyagaRajan, Srinivasan ^{[1
]}

Molinaro, Christine ^{[1
]}

Lubahn, Cheri ^{[2
]}

Lorton, Dianne ^{[2
]}

机构：

[1] Loma Linda Univ, Sch Med, Dept Pathol & Human Anat, Loma Linda, CA 92352 USA

[2] Sun Hlth Res Inst, Hoover Arthritis Ctr, Sun City, AZ 85351 USA

来源：

CELLULAR IMMUNOLOGY | 2008年 / 252卷 / 1-2期

关键词：

noradrenergic; autonomic; sympathetic innervation; lymphoid organs; immune modulation;

D O I：

10.1016/j.cellimm.2007.09.005

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Optimal host defense against pathogens requires cross-talk between nervous and immune systems. This paper reviews sympathetic-immune interaction, one major communication pathway, and its importance for health and disease. Sympathetic innervation of primary and secondary immune organs is described, as well as evidence for neurotransmission with cells of the immune system as targets. Most research thus far has focused on neural-immune modulation secondary lymphoid organs, has revealed complex sympathetic modulation resulting in both potentiation and inhibition of immune functions. SNS-immune interaction may enhance immune readiness during disease- or injury-induced 'fight' responses. Research also indicate that dysregulation of the SNS can significantly affect the progression of immune-mediated diseases. However, a better understanding of neural-immune interactions is needed to develop strategies for treatment mediated diseases that are designed to return homeostasis and restore normal functioning neural-immune networks. (C) 2008 Elsevier Inc. All rights reserved.

引用

页码：27 / 56

页数：30

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