Enabling continuous-flow chemistry in microstructured devices for pharmaceutical and fine-chemical production

被引：168

作者：

Kockmann, Norbert ^{[1
]}

Gottsponer, Michael ^{[1
]}

Zimmermann, Bertin ^{[1
]}

Roberge, Dominique M. ^{[2
]}

机构：

[1] Lonza AG, R&D Exclus Synth, Proc Optimizat, CH-3930 Visp, Switzerland

[2] Univ Ottawa, Dept Chem Engn, Ottawa, ON K1N 6N5, Canada

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2008年 / 14卷 / 25期

关键词：

lithiation; microreactors; reaction dynamics; reactor design; transport phenomena;

D O I：

10.1002/chem.200800707

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Microstructured devices offer unique transport capabilities for rapid mixing, enhanced heat and mass transfer and can handle small amounts of dangerous or unstable materials. The integration of reaction kinetics into fluid dynamics and transport phenomena is essential for successful application from process design in laboratory to chemical production. Strategies to implement production campaigns up to tons of pharmaceutical chemicals are discussed, based on Lonza projects.

引用

页码：7470 / 7477

页数：8

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