Eukaryotic Translesion Polymerases and Their Roles and Regulation in DNA Damage Tolerance

被引：464

作者：

Waters, Lauren S. ^{[1
]}

Minesinger, Brenda K. ^{[1
]}

Wiltrout, Mary Ellen ^{[1
]}

D'Souza, Sanjay ^{[1
]}

Woodruff, Rachel V. ^{[1
]}

Walker, Graham C. ^{[1
]}

机构：

[1] MIT, Dept Biol, Cambridge, MA 02139 USA

来源：

MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS | 2009年 / 73卷 / 01期

关键词：

CELL NUCLEAR ANTIGEN; DOUBLE-STRAND-BREAK; PIGMENTOSUM VARIANT CELLS; THYMINE DIMER BYPASS; SACCHAROMYCES-CEREVISIAE GENE; NUCLEOTIDE-EXCISION-REPAIR; SISTER-CHROMATID COHESION; OVARIAN-CARCINOMA CELLS; REV1 PROTEIN INTERACTS; ESCHERICHIA-COLI DINB;

D O I：

10.1128/MMBR.00034-08

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

DNA repair and DNA damage tolerance machineries are crucial to overcome the vast array of DNA damage that a cell encounters during its lifetime. In this review, we summarize the current state of knowledge about the eukaryotic DNA damage tolerance pathway translesion synthesis (TLS), a process in which specialized DNA polymerases replicate across from DNA lesions. TLS aids in resistance to DNA damage, presumably by restarting stalled replication forks or filling in gaps that remain in the genome due to the presence of DNA lesions. One consequence of this process is the potential risk of introducing mutations. Given the role of these translesion polymerases in mutagenesis, we discuss the significant regulatory mechanisms that control the five known eukaryotic translesion polymerases: Rev1, Pol zeta, Pol kappa, Pol eta, and Pol (sic).

引用

页码：134 / +

页数：22

共 280 条

[1] The in vivo characterization of translesion synthesis across UV-Induced lesions in Saccharomyces cerevisiae:: Insights into polζ- and polη-dependent frameshift mutagenesis [J].