Year in review 2010: Critical Care - multiple organ dysfunction and sepsis

被引：25

作者：

de Montmollin, Etienne ^{[1
]}

Annane, Djillali ^{[1
]}

机构：

[1] Univ Versailles St Quentin, AP HP, Hop Raymond Poincar, Serv Reanimat Polyvalente, F-92380 Garches, France

来源：

CRITICAL CARE | 2011年 / 15卷 / 06期

关键词：

ACUTE KIDNEY INJURY; GELATINASE-ASSOCIATED LIPOCALIN; TIGHT GLYCEMIC CONTROL; ACTIVATED PROTEIN-C; ENDOTHELIAL DYSFUNCTION; HYPERONCOTIC COLLOIDS; SEPTIC SHOCK; ILL PATIENTS; MORTALITY; MICROCIRCULATION;

D O I：

10.1186/cc10359

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

This review summarizes new insights in the pathophysiologic implications of inflammation and microvascular alterations in organ dysfunction, as well as genetic factor contribution, from clinical and experimental studies that were published in 2010 in Critical Care in the fields of multiple organ dysfunction and sepsis. New diagnostic and prognostic markers of organ dysfunction are presented. Evaluations of novel therapeutic strategies, including implementation of international guidelines, modulation of inflammation and coagulation, and prevention of ventilator-induced lung injury and acute kidney injury, are reported. The results of these experimental studies and clinical trials are discussed in the context of the current relevant scientific and clinical background.

引用

页数：6

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