Telomerase RNA structure and function: implications for dyskeratosis congenita

被引：117

作者：

Chen, JL ^{[1
]}

Greider, CW ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Mol Biol & Genet, Baltimore, MD 21205 USA

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2004年 / 29卷 / 04期

关键词：

D O I：

10.1016/j.tibs.2004.02.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Telomerase RNA is an intrinsic component of the telomerase enzyme. A short template sequence in the telomerase RNA is copied by the catalytic telomerase reverse transcriptase (TERT) to synthesize telomere repeats to chromosome ends. In addition to the template, other conserved RNA structural elements play important parts in catalysis as well as localization, maturation and assembly of telomerase. Telomerase RNA is mutated in the autosomal dominant form of the disease dyskeratosis congenita. Recent studies of telomerase RNA function and telomerase biogenesis have provided a basis for understanding the role of telomerase in this disease.

引用

页码：183 / 192

页数：10

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