Adiposity, mediating biomarkers and risk of colon cancer in the European Prospective Investigation into Cancer and Nutrition Study

被引：34

作者：

Aleksandrova, Krasimira ^{[1
]}

Drogan, Dagmar ^{[1
]}

Boeing, Heiner ^{[1
]}

Jenab, Mazda ^{[2
]}

Bueno-de-Mesquita, H. Bas ^{[3
,4
]}

Jansen, Eugene ^{[3
]}

van Duijnhoven, Fraenzel J. B. ^{[3
,5
]}

Rinaldi, Sabina ^{[2
]}

Fedirko, Veronika ^{[2
,6
]}

Romieu, Isabelle ^{[2
]}

Kaaks, Rudolf ^{[7
]}

Riboli, Elio ^{[8
]}

Gunter, Marc J. ^{[8
]}

Romaguera, Dora ^{[8
]}

Westhpal, Sabine ^{[9
]}

Overvad, Kim ^{[10
]}

Tjonneland, Anne ^{[11
]}

Halkjaer, Jytte ^{[11
]}

Boutron-Ruault, Marie-Christine ^{[12
,13
]}

Clavel-Chapelon, Francoise ^{[12
,13
]}

Lukanova, Annekatrin ^{[7
]}

Trichopoulou, Antonia ^{[14
,15
]}

Trichopoulos, Dimitrios ^{[15
,16
,17
]}

Vidalis, Pavlos ^{[15
]}

Panico, Salvatore ^{[18
]}

Agnoli, Claudia ^{[19
]}

Palli, Domenico ^{[20
]}

Tumino, Rosario ^{[21
,22
]}

Vineis, Paolo ^{[8
,23
]}

Buckland, Genevieve ^{[24
]}

Sanchez-Cruz, Jose-Juan ^{[25
]}

Dorronsoro, Miren ^{[26
]}

Tormo Diaz, Maria Jose ^{[27
,28
,29
]}

Barricarte, Aurelio ^{[30
]}

Ramon Quiros, J. ^{[31
]}

Peeters, Petra H. ^{[8
,32
]}

May, Anne M. ^{[32
]}

Hallmans, Goran ^{[33
]}

Palmqvist, Richard ^{[34
]}

Crowe, Francesca L. ^{[35
]}

Khaw, Kay-Tee ^{[36
,37
]}

Wareham, Nickolas ^{[36
,37
]}

Pischon, Tobias ^{[1
,38
]}

机构：

[1] German Inst Human Nutr Potsdam Rehbrucke, Dept Epidemiol, D-14558 Nuthetal, Germany

[2] Int Agcy Res Canc IARC WHO, Lyon, France

[3] Natl Inst Publ Hlth & Environm RIVM, Bilthoven, Netherlands

[4] Univ Med Ctr, Dept Gastroenterol & Hepatol, Utrecht, Netherlands

[5] Wageningen Univ, Div Human Nutr, NL-6700 AP Wageningen, Netherlands

[6] Emory Univ, Rollins Sch Publ Hlth, Dept Epidemiol, Atlanta, GA 30322 USA

[7] German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany

[8] Univ London Imperial Coll Sci Technol & Med, Div Epidemiol Publ Hlth & Primary Care, London, England

[9] Otto Von Guericke Univ, Inst Clin Chem, Magdeburg, Germany

[10] Aarhus Univ, Sch Publ Hlth, Dept Epidemiol, Aarhus, Denmark

[11] Danish Canc Soc, Dept Diet Genes & Environm, Res Ctr, Copenhagen, Denmark

[12] Inst Gustave Roussy, INSERM, Ctr Res Epidemiol & Populat Hlth, U1018, F-94805 Villejuif, France

[13] Paris South Univ, UMRS 1018, Villejuif, France

[14] Univ Athens, Sch Med, WHO Collaborating Ctr Food & Nutr Policies, Dept Hyg Epidemiol & Med Stat, GR-11527 Athens, Greece

[15] Hellen Hlth Fdn, Athens, Greece

[16] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA

[17] Acad Athens, Bur Epidemiol Res, Athens, Greece

[18] Univ Naples Federico II, Dept Clin & Expt Med, Naples, Italy

[19] Fdn IRCCS Ist Nazl Tumori, Nutr Epidemiol Unit, Milan, Italy

[20] Canc Res & Prevent Inst ISPO, Mol & Nutr Epidemiol Unit, Florence, Italy

[21] MP Arezzo Hosp, Canc Registry, Ragusa, Italy

[22] MP Arezzo Hosp, Histopathol Unit, Ragusa, Italy

[23] HuGeF Fdn, Turin, Italy

[24] Catalan Inst Oncol ICO IDIBELL, Canc Epidemiol Res Programme, Unit Nutr Environm & Canc, Barcelona, Spain

[25] Andalusian Sch Publ Hlth, Granada, Spain

[26] Basque Reg Hlth Dept, Publ Hlth Div Gipuzkoa, San Sebastian, Spain

[27] Consejeria Sanidad & Polit Social, Dept Epidemiol, Serv Epidemiol, Murcia, Spain

[28] CIBER Epidemiol & Salud Publ CIBERESP, Reg Hlth Council, Barcelona, Spain

[29] Murcia Sch Med, Fac Med Murcia, Murcia, Spain

[30] Navarre Publ Hlth Inst, Pamplona, Spain

[31] Publ Hlth Directorate, Asturias, Spain

[32] Univ Med Ctr, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands

[33] Umea Univ, Dept Publ Hlth & Clin Med, Umea, Sweden

[34] Umea Univ, Dept Med Biosci, Umea, Sweden

[35] Univ Oxford, Nuffield Dept Clin Med, Canc Epidemiol Unit, Oxford, England

[36] Med Res Council UK, London, England

[37] Canc Res UK, London, England

[38] Max Delbrueck Ctr Mol Med MDC, Mol Epidemiol Grp, Berlin, Germany

来源：

INTERNATIONAL JOURNAL OF CANCER | 2014年 / 134卷 / 03期

关键词：

colon cancer; adiposity; waist circumference; body mass index; mediating biomarkers; DENSITY-LIPOPROTEIN CHOLESTEROL; COLORECTAL-CANCER; RECTAL-CANCER; C-PEPTIDE; ADIPONECTIN; LEPTIN; HDL; IGFBP-3; OBESITY; WEIGHT;

D O I：

10.1002/ijc.28368

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Adiposity is a risk factor for colon cancer, but underlying mechanisms are not well understood. We evaluated the extent to which 11 biomarkers with inflammatory and metabolic actions mediate the association of adiposity measures, waist circumference (WC) and body mass index (BMI), with colon cancer in men and women. We analyzed data from a prospective nested case-control study among 662 incident colon cancer cases matched within risk sets to 662 controls. Relative risks (RRs) and 95% confidence intervals (CIs) were calculated using conditional logistic regression. The percent effect change and corresponding CIs were estimated after adjusting for biomarkers shown to be associated with colon cancer risk. After multivariable adjustment, WC was associated with colon cancer risk in men (top vs. bottom tertile RR 1.68, 95% CI 1.06-2.65; p(trend)=0.02) and in women (RR 1.67, 95% CI 1.09-2.56; p(trend)=0.03). BMI was associated with risk only in men. The association of WC with colon cancer was accounted mostly for by three biomarkers, high-density lipoprotein cholesterol, non-high-molecular-weight adiponectin and soluble leptin receptor, which in combination explained 46% (95% CI 37-57%) of the association in men and 50% (95% CI 40-65%) of the association in women. Similar results were observed for the associations with BMI in men. These data suggest that alterations in levels of these metabolic biomarkers may represent a primary mechanism of action in the relation of adiposity with colon cancer. Further studies are warranted to determine whether altering their concentrations may reduce colon cancer risk. What's new? Adiposity is a well-established risk factor for colon cancer. However, the mechanisms that underlie this relationship still aren't well understood. In this study, the authors evaluated a panel of inflammatory and metabolic biomarkers for their impact on colon-cancer risk. They found that serum levels of high-density lipoprotein cholesterol, non-high-molecular-weight adiponectin, and soluble leptin receptor had the greatest impact on the association between adiposity and colon cancer. These biomarkers may thus lead to promising strategies for the targeted prevention of colon cancer.

引用

页码：612 / 621

页数：10

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