New efficient catalysts for enantioselective transfer hydrogenations

被引：100

作者：

Puntener, K ^{[1
]}

Schwink, L ^{[1
]}

Knochel, P ^{[1
]}

机构：

[1] UNIV MARBURG,FACHBEREICH CHEM,D-35032 MARBURG,GERMANY

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 45期

关键词：

D O I：

10.1016/0040-4039(96)01853-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

New C-2-symmetrical diaminoferrocenyl derivatives 3 and 2-amino(sulfonamido)cyclohexanes 4 were found to be highly active ligands for the ruthenium catalyzed asymmetric transfer hydrogenation of ketones. Contrary to many existing catalytic systems, the ligands 3 show a high activity at 25 degrees C and operate even at -30 degrees C (up to 90 % ee). On the other hand, the slightly less active ligands 4 are very easily prepared and are highly enantioselective at 30 degrees C in HCOOH/Et(3)N (up to 96 % ee). Copyright (C) 1996 Elsevier Science Ltd

引用

页码：8165 / 8168

页数：4

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