Immune modulation by Pseudomonas aeruginosa quorum-sensing signal molecules

被引：40

作者：

Pritchard, DI ^{[1
]}

机构：

[1] Univ Nottingham, Sch Pharm, Immune Modulat Res Grp, Nottingham NG7 2RD, England

来源：

INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY | 2006年 / 296卷 / 2-3期

基金：

英国医学研究理事会;

关键词：

Pseudomonas aeruginosa; quorum sensing; N-(3-oxododecanoyl)-L-homoserine lactone; 2-heptyl-3-hydroxy-4-quinolone; PQS; T cells; cytokines;

D O I：

10.1016/j.ijmm.2006.01.037

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

There is burgeoning recent interest in the potential of bacterial quorum-sensing signal molecules (QSSMs) such as the long chain N-acylhomoserine lactones (AHLs) and 4-quinolones produced by Pseudomonas aeruginosa for modulating immune function. While it is clear that QSSMs have well defined immune modulatory potential in vitro, and are detectable in body fluids (such as sputum from cystic fibrosis patients infected with P. aeruginosa) at levels which might be expected to modify immune competence, the true impact of bacterial QSSMs on host physiology in vivo has yet to be fully determined. (c) 2006 Published by Elsevier GmbH.

引用

页码：111 / 116

页数：6

共 31 条

[1]

Atkinson S, 2006, CURR ISSUES MOL BIOL, V8, P1

[2] Pseudomonas aeruginosa tolerance to tobramycin, hydrogen peroxide and polymorphonuclear leukocytes is quorum-sensing dependent [J].

Bjarnsholt, T ;

Jensen, PO ;

Burmolle, M ;

Hentzer, M ;

Haagensen, JAJ ;

Hougen, HP ;

Calum, H ;

Madsen, KG ;

Moser, C ;

Molin, S ;

Hoiby, N ;

Givskov, M .

MICROBIOLOGY-SGM, 2005, 151 :373-383

[3] Identification of N-acylhomoserine lactones in mucopurulent respiratory secretions from cystic fibrosis patients [J].

Chambers, CE ;

Visser, MB ;

Schwab, U ;

Sokol, PA .

FEMS MICROBIOLOGY LETTERS, 2005, 244 (02) :297-304

[4] Synthetic analogues of the bacterial signal (quorum sensing) molecule N-(3-oxododecanoyl)-L-homoserine lactone as immune modulators [J].

Chhabra, SR ;

Harty, C ;

Hooi, DSW ;

Daykin, M ;

Williams, P ;

Telford, G ;

Pritchard, DI ;

Bycroft, BW .

JOURNAL OF MEDICINAL CHEMISTRY, 2003, 46 (01) :97-104

[5] A bacterial cell to cell signal in the lungs of cystic fibrosis patients [J].

Collier, DN ;

Anderson, L ;

McKnight, SL ;

Noah, TL ;

Knowles, M ;

Boucher, R ;

Schwab, U ;

Gilligan, P ;

Pesci, EC .

FEMS MICROBIOLOGY LETTERS, 2002, 215 (01) :41-46

[6] Analysis of Pseudomonas aeruginosa 4-hydroxy-2-alkylquinolines (HAQs) reveals a role for 4-hydroxy-2-heptylquinoline in cell-to-cell communication [J].

Déziel, E ;

Lépine, F ;

Milot, S ;

He, JX ;

Mindrinos, MN ;

Tompkins, RG ;

Rahme, LG .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (05) :1339-1344

[7] 4-Quinolone signalling in Pseudomonas aeruginosa:: Old molecules, new perspectives [J].

Diggle, SP ;

Cornelis, P ;

Williams, P ;

Cámara, M .

INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY, 2006, 296 (2-3) :83-91

[8] The Pseudomonas aeruginosa quinolone signal molecule overcomes the cell density-dependency of the quorum sensing hierarchy, regulates rhl-dependent genes at the onset of stationary phase and can be produced in the absence of LasR [J].

Diggle, SP ;

Winzer, K ;

Chhabra, SR ;

Worrall, KE ;

Cámara, M ;

Williams, P .

MOLECULAR MICROBIOLOGY, 2003, 50 (01) :29-43

[9] Quorum sensing and its relevance to infectious diseases [J].

Donabedian, H .

JOURNAL OF INFECTION, 2003, 46 (04) :207-214

[10] Quorum sensing in the genus Burkholderia [J].

Eberl, L .

INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY, 2006, 296 (2-3) :103-110

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