Tumor necrosis factor-alpha in response to endotoxin administration in the pregnant guinea pig

被引:6
作者
Beckmann, I
MeiselMikolajczyk, F
Lotgering, FK
Wallenburg, HCS
机构
[1] ERASMUS UNIV ROTTERDAM,SCH MED & HLTH SCI,INST OBSTET & GYNECOL,NL-3000 DR ROTTERDAM,NETHERLANDS
[2] MED ACAD WARSAW,INST BIOSTRUCT,DEPT CLIN BACTERIOL,PL-02032 WARSAW,POLAND
关键词
tumor necrosis factor-alpha; Bacteroides fragilis endotoxin; pregnant guinea pig; prostacyclin;
D O I
10.1016/S0002-9378(96)70278-8
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
OBJECTIVE: Our purpose was to test the hypothesis that an intramuscular endotoxin challenge induces production of tumor necrosis factor-alpha in the pregnant guinea pig and to investigate some of the metabolic effects. STUDY DESIGN: Twelve randomly selected guinea pigs at 33 days' gestation with a sampling catheter in the carotid artery received an intramuscular injection of a solution of endotoxin isolated from Bacteroides fragilis (n = 6) or of solvent alone (n = 6). Plasma values of tumor necrosis factor-alpha, hematocrit, and 6-keto-prostaglandin F-1 alpha were determined before and several hours after injection. RESULTS: Tumor necrosis factor-alpha was detected in five of six guinea pigs, but it could not be demonstrated in five or six placebo animals. The hematocrit was significantly decreased, and prostaglandin F-1 alpha significantly increased 24 to 48 hours after endotoxin injection. CONCLUSION: In pregnant guinea pigs an intramuscular endotoxin challenge induces the release of tumor necrosis factor-alpha, followed by a reduced hematocrit and an increased prostacyclin concentration. These effects could be involved in the pathogenesis of endotoxin-induced fetal growth retardation.
引用
收藏
页码:218 / 221
页数:4
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