Th17 Cells in Immunity and Autoimmunity

被引：205

作者：

Bedoya, Simone Kennedy ^{[1
]}

Lam, Brandon ^{[1
]}

Lau, Kenneth ^{[1
]}

Larkin, Joseph, III ^{[1
]}

机构：

[1] Univ Florida, Dept Microbiol & Cell Sci, Gainesville, FL 32611 USA

来源：

CLINICAL & DEVELOPMENTAL IMMUNOLOGY | 2013年

关键词：

REGULATORY T-CELLS; INFLAMMATORY-BOWEL-DISEASE; GROWTH-FACTOR-BETA; SYSTEMIC-LUPUS-ERYTHEMATOSUS; ARYL-HYDROCARBON RECEPTOR; NONOBESE DIABETIC MICE; ENTERICA SEROVAR ENTERITIDIS; GENOME-WIDE ASSOCIATION; PATHOGENIC T(H)17 CELLS; ROR-GAMMA-T;

D O I：

10.1155/2013/986789

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Th17 and IL-17 play important roles in the clearance of extracellular bacterial and fungal infections. However, strong evidence also implicates the Th17 lineage in several autoimmune disorders including multiple sclerosis, psoriasis, rheumatoid arthritis, inflammatory bowel disease, systemic lupus erythematosus, and asthma. The Th17 subset has also been connected with type I diabetes, although whether it plays a role in the pathogenicity of or protection from the disease remains a controversial issue. In this review we have provided a comprehensive overview of Th17 pathogenicity and function, including novel evidence for a protective role of Th17 cells in conjunction with the microbiota gut flora in T1D onset and progression.

引用

页数：16

共 243 条

[1]

Interleukins 1β and 6 but not transforming growth factor-β are essential for the differentiation of interleukin 17-producing human T helper cells [J].

Acosta-Rodriguez, Eva V. ;

Napolitani, Giorgio ;

Lanzavecchia, Antonio ;

Sallusto, Federica .

NATURE IMMUNOLOGY, 2007, 8 (09) :942-949

[2]

Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells [J].

Acosta-Rodriguez, Eva V. ;

Rivino, Laura ;

Geginat, Jens ;

Jarrossay, David ;

Gattorno, Marco ;

Lanzavecchia, Antonio ;

Sallusto, Federica ;

Napolitani, Giorgio .

NATURE IMMUNOLOGY, 2007, 8 (06) :639-646

[3]

Effects of a germ-free environment on gut immune regulation and diabetes progression in non-obese diabetic (NOD) mice [J].

Alam, C. ;

Bittoun, E. ;

Bhagwat, D. ;

Valkonen, S. ;

Saari, A. ;

Jaakkola, U. ;

Eerola, E. ;

Huovinen, P. ;

Hanninen, A. .

DIABETOLOGIA, 2011, 54 (06) :1398-1406

[4]

Balance between Regulatory T and Th17 Cells in Systemic Lupus Erythematosus: The Old and the New [J].

Alunno, Alessia ;

Bartoloni, Elena ;

Bistoni, Onelia ;

Nocentini, Giuseppe ;

Ronchetti, Simona ;

Caterbi, Sara ;

Valentini, Valentina ;

Riccardi, Carlo ;

Gerli, Roberto .

CLINICAL & DEVELOPMENTAL IMMUNOLOGY, 2012,

[5]

TH17 cells contribute to uveitis and scleritis and are expanded by IL-2 and inhibited by IL-27/STAT1 [J].

Amadi-Obi, Ahjoku ;

Yu, Cheng-Rong ;

Liu, Xuebin ;

Mahdi, Rashid M. ;

Clarke, Grace Levy ;

Nussenblatt, Robert B. ;

Gery, Igal ;

Lee, Yun Sang ;

Egwuagu, Charles E. .

NATURE MEDICINE, 2007, 13 (06) :711-718

[6]

Phenotypic and functional features of human Th17 cells [J].

Annunziato, Francesco ;

Cosmi, Lorenzo ;

Santarlasci, Veronica ;

Maggi, Laura ;

Liotta, Francesco ;

Mazzinghi, Benedetta ;

Parente, Eliana ;

Fili, Lucia ;

Ferri, Simona ;

Frosali, Francesca ;

Giudici, Francesco ;

Romagnani, Paola ;

Parronchi, Paola ;

Tonelli, Francesco ;

Maggi, Enrico ;

Romagnani, Sergio .

JOURNAL OF EXPERIMENTAL MEDICINE, 2007, 204 (08) :1849-1861

[7]

[Anonymous], 2013, DYP 1 DIAB FACT SHEE

[8]

Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation:: Evidence in Crohn disease and experimental colitis in vivo [J].

Atreya, R ;

Mudter, J ;

Finotto, S ;

Müllberg, J ;

Jostock, T ;

Wirtz, S ;

Schütz, M ;

Bartsch, B ;

Holtmann, M ;

Becker, C ;

Strand, D ;

Czaja, J ;

Schlaak, JF ;

Lehr, HA ;

Autschbach, F ;

Schürmann, G ;

Nishimoto, N ;

Yoshizaki, K ;

Ito, H ;

Kishimoto, T ;

Galle, PR ;

Rose-John, S ;

Neurath, MF .

NATURE MEDICINE, 2000, 6 (05) :583-588

[9]

Interleukin-17 up-regulation of nitric oxide production in human osteoarthritis cartilage [J].

Attur, MG ;

Patel, RN ;

Abramson, SB ;

Amin, AR .

ARTHRITIS AND RHEUMATISM, 1997, 40 (06) :1050-1053

[10]

Defective Differentiation of Regulatory FoxP3+ T Cells by Small-Intestinal Dendritic Cells in Patients With Type 1 Diabetes [J].

Badami, Ester ;

Sorini, Chiara ;

Coccia, Margherita ;

Usuelli, Vera ;

Molteni, Laura ;

Bolla, Andrea Mario ;

Scavini, Marina ;

Mariani, Alberto ;

King, Cecile ;

Bosi, Emanuele ;

Falcone, Marika .

DIABETES, 2011, 60 (08) :2120-2124

← 1 2 3 4 5 6 7 8 9 10 →