Synthesis of chiral plane-extended pyridyl alcohols for the enantioselective addition of diethylzinc to aldehydes

被引：28

作者：

Kang, JY ^{[1
]}

Kim, HY

Kim, JH

机构：

[1] Sogang Univ, Dept Chem, Seoul 121742, South Korea

[2] Korea Inst Sci & Technol, Biochem Res Ctr, Seoul 130650, South Korea

来源：

TETRAHEDRON-ASYMMETRY | 1999年 / 10卷 / 13期

关键词：

D O I：

10.1016/S0957-4166(99)00247-5

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Enantiomerically pure pyridyl alcohols, 1 and 2, were prepared from readily available racemic pyridyl alcohol 3 and applied to the enantioselective addition of diethylzinc to aldehydes resulting in moderately high enantiomeric excess (90%) in the case of benzaldehyde. In this study the first example of an alteration in the configuration of the product upon change of a non-chiral and non-coordinating part of the catalyst was observed. (C) 1999 Elsevier Science Ltd. All rights reserved.

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页码：2523 / 2533

页数：11

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