The emerging significance of O-GlcNAc in cellular regulation

被引：248

作者：

Zachara, NE ^{[1
]}

Hart, GW ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Biol Chem, Baltimore, MD 21205 USA

来源：

CHEMICAL REVIEWS | 2002年 / 102卷 / 02期

关键词：

D O I：

10.1021/cr000406u

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Recently, perturbations in the regulation of O-GlcNAc were implicated in the etiology of type II diabetes, cancer, and neurodegenerative diseases. O-GlcNAc, the modification of Ser and Thr residues of nuclear and cytoplasmic proteins with O-linked β-N-acetylglucosamine, is one of a growing number of posttranslational modifications of proteins thought to modulate the function/activity of proteins in cells. This paper reviews the current understanding of the importance of the unique carbohydrate modification O-GlcNAc, in regulating functions within the cell.

引用

页码：431 / 438

页数：8

共 127 条

[1] Hyperglycemia and the O-GlcNAc transferase in rat aortic smooth muscle cells: Elevated expression and altered patterns of O-GlcNAcylation [J].

Akimoto, Y ;

Kreppel, LK ;

Hirano, H ;

Hart, GW .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 2001, 389 (02) :166-175

[2] The microtubule-associated protein tau is extensively modified with O-linked N-acetylglucosamine [J].

Arnold, CS ;

Johnson, GVW ;

Cole, RN ;

Dong, DLY ;

Lee, M ;

Hart, GW .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (46) :28741-28744

[3] Dynamic cytoskeletal glycosylation and neurodegenerative disease [J].

Arnold, CS ;

Hart, GW .

TRENDS IN GLYCOSCIENCE AND GLYCOTECHNOLOGY, 1999, 11 (62) :355-370

[4] THE LA ANTIGEN SHUTTLES BETWEEN THE NUCLEUS AND THE CYTOPLASM IN CV-1 CELLS [J].

BACHMANN, M ;

PFEIFER, K ;

SCHRODER, HC ;

MULLER, WEG .

MOLECULAR AND CELLULAR BIOCHEMISTRY, 1989, 85 (02) :103-114

[5] Glucosamine induces insulin resistance in vivo by affecting GLUT 4 translocation in skeletal muscle - Implications for glucose toxicity [J].

Baron, AD ;

Zhu, JS ;

Weldon, H ;

Maianu, L ;

Garvey, WT .

JOURNAL OF CLINICAL INVESTIGATION, 1995, 96 (06) :2792-2801

[6] Evidence for genetic linkage of Alzheimer's disease to chromosome 10q [J].

Bertram, L ;

Blacker, D ;

Mullin, K ;

Keeney, D ;

Jones, J ;

Basu, S ;

Yhu, S ;

McInnis, MG ;

Go, RCP ;

Vekrellis, K ;

Selkoe, DJ ;

Saunders, AJ ;

Tanzi, RE .

SCIENCE, 2000, 290 (5500) :2302-+

[7] Decreased UDP-GlcNAc levels abrogate proliferation control in EMeg32-deficient cells [J].

Boehmelt, G ;

Wakeham, A ;

Elia, A ;

Sasaki, T ;

Plyte, S ;

Potter, J ;

Yang, YJ ;

Tsang, E ;

Ruland, J ;

Iscove, NN ;

Dennis, JW ;

Mak, TW .

EMBO JOURNAL, 2000, 19 (19) :5092-5104

[8] MAJOR NUCLEOLAR PROTEINS SHUTTLE BETWEEN NUCLEUS AND CYTOPLASM [J].

BORER, RA ;

LEHNER, CF ;

EPPENBERGER, HM ;

NIGG, EA .

CELL, 1989, 56 (03) :379-390

[9] CHARACTERIZATION OF HUMAN N-ACETYL-BETA-HEXOSAMINIDASE-C [J].

BRAIDMAN, I ;

CARROLL, M ;

DANCE, N ;

ROBINSON, D ;

POENARU, L ;

WEBER, A ;

DREYFUS, JC ;

OVERDIJK, B ;

HOOGHWINKEL, GJ .

FEBS LETTERS, 1974, 41 (02) :181-184

[10] ROLE OF ALPHA-LACTALBUMIN AND A PROTEIN IN LACTOSE SYNTHETASE - A UNIQUE MECHANISM FOR CONTROL OF A BIOLOGICAL REACTION [J].

BREW, K ;

VANAMAN, TC ;

HILL, RL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1968, 59 (02) :491-&

← 1 2 3 4 5 6 7 8 9 10 →