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R5 strains of human immunodeficiency virus type 1 from rapid progressors lacking X4 strains do not possess X4-type pathogenicity in human thymus

被引：16
作者：
Berkowitz, RD
van't Wout, AB
Kootstra, NA
Moreno, ME
Linquist-Stepps, VD
Bare, C
Stoddart, CA
Schuitemaker, H
McCune, JM
机构：
[1] Univ Calif San Francisco, Gladstone Inst Virol & Immunol, San Francisco, CA 94141 USA
[2] Univ Calif San Francisco, Dept Microbiol & Immunol, San Francisco, CA 94141 USA
[3] Univ Calif San Francisco, Dept Med, San Francisco, CA 94141 USA
[4] Univ Amsterdam, Expt & Clin Immunol Lab, Amsterdam, Netherlands
[5] Netherlands Red Cross, Blood Transfus Serv, Cent Lab, Dept Clin Viroimmunol, Amsterdam, Netherlands
来源：
JOURNAL OF VIROLOGY | 1999年 / 73卷 / 09期
关键词：
D O I：
10.1128/JVI.73.9.7817-7822.1999
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Some individuals infected with only R5 strains of human immunodeficiency virus type 1 progress to AIDS as quickly as individuals harboring X4 strains. We determined that three R5 viruses were much less pathogenic than an X4 virus in SCID-hu Thy/Liv mice, suggesting that R5 virus-mediated rapid disease progression is associated with host, not viral, factors.
引用
收藏
页码：7817 / 7822
页数：6
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