R5 strains of human immunodeficiency virus type 1 from rapid progressors lacking X4 strains do not possess X4-type pathogenicity in human thymus

被引：16

作者：

Berkowitz, RD

van't Wout, AB

Kootstra, NA

Moreno, ME

Linquist-Stepps, VD

Bare, C

Stoddart, CA

Schuitemaker, H

McCune, JM

机构：

[1] Univ Calif San Francisco, Gladstone Inst Virol & Immunol, San Francisco, CA 94141 USA

[2] Univ Calif San Francisco, Dept Microbiol & Immunol, San Francisco, CA 94141 USA

[3] Univ Calif San Francisco, Dept Med, San Francisco, CA 94141 USA

[4] Univ Amsterdam, Expt & Clin Immunol Lab, Amsterdam, Netherlands

[5] Netherlands Red Cross, Blood Transfus Serv, Cent Lab, Dept Clin Viroimmunol, Amsterdam, Netherlands

来源：

JOURNAL OF VIROLOGY | 1999年 / 73卷 / 09期

关键词：

D O I：

10.1128/JVI.73.9.7817-7822.1999

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Some individuals infected with only R5 strains of human immunodeficiency virus type 1 progress to AIDS as quickly as individuals harboring X4 strains. We determined that three R5 viruses were much less pathogenic than an X4 virus in SCID-hu Thy/Liv mice, suggesting that R5 virus-mediated rapid disease progression is associated with host, not viral, factors.

引用

收藏

页码：7817 / 7822

页数：6

相关论文

共 31 条

[11]

CAMERINI D, COMMUNICATION

[12] HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 VARIANTS WITH INCREASED REPLICATIVE CAPACITY DEVELOP DURING THE ASYMPTOMATIC STAGE BEFORE DISEASE PROGRESSION [J].

CONNOR, RI ;

HO, DD .

JOURNAL OF VIROLOGY, 1994, 68 (07) :4400-4408

[13] Macrophage inflammatory protein-1β induces migration and activation of human thymocytes [J].

Dairaghi, DJ ;

Franz-Bacon, K ;

Callas, E ;

Cupp, J ;

Schall, TJ ;

Tamraz, SA ;

Boehme, SA ;

Taylor, N ;

Bacon, KB .

BLOOD, 1998, 91 (08) :2905-2913

[14] THE ROLE OF MONONUCLEAR PHAGOCYTES IN HTLV-III LAV INFECTION [J].

GARTNER, S ;

MARKOVITS, P ;

MARKOVITZ, DM ;

KAPLAN, MH ;

GALLO, RC ;

POPOVIC, M .

SCIENCE, 1986, 233 (4760) :215-219

[15] CCR5- and CXCR4-tropic HIV-1 are equally cytopathic for their T-cell targets in human lymphoid tissue [J].

Grivel, JC ;

Margolis, LB .

NATURE MEDICINE, 1999, 5 (03) :344-346

[16] IN-VIVO PATHOGENIC PROPERTIES OF 2 CLONAL HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 ISOLATES [J].

JAMIESON, BD ;

PANG, S ;

ALDROVANDI, GM ;

ZHA, JL ;

ZACK, JA .

JOURNAL OF VIROLOGY, 1995, 69 (10) :6259-6264

[17] RAPID-HIGH, SYNCYTIUM-INDUCING ISOLATES OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 INDUCE CYTOPATHICITY IN THE HUMAN THYMUS OF THE SCID-HU MOUSE [J].

KANESHIMA, H ;

SU, LS ;

BONYHADI, ML ;

CONNOR, RI ;

HO, DD ;

MCCUNE, JM .

JOURNAL OF VIROLOGY, 1994, 68 (12) :8188-8192

[18] CXCR4 expression during lymphopoiesis: Implications for human immunodeficiency virus type 1 infection of the thymus [J].

Kitchen, SG ;

Zack, JA .

JOURNAL OF VIROLOGY, 1997, 71 (09) :6928-6934

[19] PROGNOSTIC VALUE OF HIV-1 SYNCYTIUM-INDUCING PHENOTYPE FOR RATE OF CD4+ CELL DEPLETION AND PROGRESSION TO AIDS [J].

KOOT, M ;

KEET, IPM ;

VOS, AHV ;

DEGOEDE, REY ;

ROOS, MTL ;

COUTINHO, RA ;

MIEDEMA, F ;

SCHELLEKENS, PTA ;

TERSMETTE, M .

ANNALS OF INTERNAL MEDICINE, 1993, 118 (09) :681-688

[20] Proliferation-dependent replication in primary macrophages of macrophage-tropic HIV type 1 variants [J].

Kootstra, NA ;

Schuitemaker, H .

AIDS RESEARCH AND HUMAN RETROVIRUSES, 1998, 14 (04) :339-345

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