Discovery of imidazol[1,2-c]pyrimidin-5(6H)-one heterosubstituted nucleoside analogues with potent activity against human hepatitis B virus in vitro

被引：21

作者：

Mansour, TS ^{[1
]}

Evans, CA ^{[1
]}

Charron, M ^{[1
]}

Korba, BE ^{[1
]}

机构：

[1] GEORGETOWN UNIV,DIV MOL VIROL & IMMUNOL,ROCKVILLE,MD 20852

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 03期

关键词：

D O I：

10.1016/S0960-894X(97)00001-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The in vitro antihepatitis B virus (HBV) activities of eleven novel imidazo[1,2-c]pyrimidin-5(6H)-one dideoxynucleoside analogues in which the sugar ring is 1,3-dioxolane or 1,3-oxathiolane were compared in the chronically HBV-producing human cell line 2.2.15. Seven nucleoside analogues 4, 9, 10, 15, 16, Is, and 24, of which 16 possesses the tra,ls relative stereochemistry, displayed good potency and selectivity towards HBV. The order of decreasing potency at the 90% extracellular DNA inhibition level was 15>16>24 approximate to 9>10>18. None of the tested imidazo[1,2-c]pyrimidines inhibited the replication of HIV-1 in MT-4 cells. (C) 1997, Elsevier Science Ltd.

引用

页码：303 / 308

页数：6

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