Discontinuous deletions at 11q23 in B cell chronic lymphocytic leukemia

被引：29

作者：

Zhu, Y

Monni, O

El-Rifai, W

Siitonen, SM

Vilpo, L

Vilpo, J

Knuutila, S

机构：

[1] Univ Helsinki, Cent Hosp, Med Genet Lab, FIN-00029 Helsinki, Finland

[2] Univ Helsinki, Haartman Inst, Dept Med Genet, Helsinki, Finland

[3] Natl Res Ctr, Dept Human Genet, Cairo, Egypt

[4] Tampere Univ Hosp, Dept Clin Chem, Tampere, Finland

[5] Tampere Univ, Sch Med, FIN-33101 Tampere, Finland

来源：

LEUKEMIA | 1999年 / 13卷 / 05期

关键词：

B cell chronic lymphocytic leukemia; fluorescence in situ hybridization; yeast artificial chromosome; deletions at 11q23;

D O I：

10.1038/sj.leu.2401405

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Loss of genomic material in 11q is one of the most common structural chromosome aberrations in B cell chronic lymphocytic leukemia (B-CLL). In order to characterize the deletions of 11q23 in B-CLL, we performed fluorescence in situ hybridization (FISH) with eight YAC (yeast artificial chromosome) probes on peripheral leukocytes of 30 patients. These YACs form a contig spanning 7.8 Mb at 11q23.1-q23.3. We found deletions in nine out of 30 cases (30%) and five of them had discontinuous deletions in this region. The region represented by YAC 755b11 (1.6 Mb in size) was involved in all cases with deletions, supporting the hypothesis that this region might contain a novel gene of pathogenic importance to B-CLL. A more distal region represented by YAC 785e12 (760 kb in size) was deleted frequently and specifically. Whether there is another novel gene of pathogenic importance to B-CLL and what is its potential relationship to the deletions in the region represented by YAC 755b11, are issues that require further studies.

引用

页码：708 / 712

页数：5