Lipid-insertion enables targeting functionalization of erythrocyte membrane-cloaked nanoparticles

被引：304

作者：

Fang, Ronnie H. ^{[1
,2
]}

Hu, Che-Ming J. ^{[1
,2
]}

Chen, Kevin N. H. ^{[1
]}

Luk, Brian T. ^{[2
,3
]}

Carpenter, Cody W. ^{[1
]}

Gao, Weiwei ^{[1
,2
]}

Li, Shulin ^{[4
]}

Zhang, Dong-Er ^{[2
]}

Lu, Weiyue ^{[5
,6
]}

Zhang, Liangfang ^{[1
,2
]}

机构：

[1] Univ Calif San Diego, Dept NanoEngn, La Jolla, CA 92093 USA

[2] Univ Calif San Diego, Moores Canc Ctr, La Jolla, CA 92093 USA

[3] Univ Calif San Diego, Dept Bioengn, La Jolla, CA 92093 USA

[4] Univ Texas MD Anderson Canc Ctr, Dept Pediat Res, Houston, TX 77030 USA

[5] Sch Fudan Univ, Key Lab Smart Drug Delivery, Minist Educ, Shanghai 201203, Peoples R China

[6] Sch Fudan Univ, PLA, Sch Pharm, Shanghai 201203, Peoples R China

来源：

NANOSCALE | 2013年 / 5卷 / 19期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

CULTURED KB CELLS; RED-BLOOD-CELLS; DRUG-DELIVERY; FOLATE-RECEPTOR; CANCER-CELLS; THERAPEUTICS; SYSTEMS; NANOMEDICINE; PERMEABILITY; NUCLEOLIN;

D O I：

10.1039/c3nr03064d

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

RBC membrane-cloaked polymeric nanoparticles represent an emerging nanocarrier platform with extended circulation in vivo. A lipid-insertion method is employed to functionalize these nanoparticles without the need for direct chemical conjugation. Insertion of both folate and the nucleolin-targeting aptamer AS1411 shows receptor-specific targeting against model cancer cell lines.

引用

页码：8884 / 8888

页数：5

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