Confounding in evaluating the effectiveness of influenza vaccine

被引：15

作者：

Mori, Mitsuru ^{[1
]}

Oura, Asae ^{[1
]}

Ohnishi, Hirofumi ^{[1
]}

Washio, Masakazu ^{[2
]}

机构：

[1] Sapporo Med Univ, Sch Med, Dept Publ Hlth, Chuo Ku, Sapporo, Hokkaido 0608556, Japan

[2] St Marys Coll, Dept Community Hlth & Clin Epidemiol, Fukuoka 8308556, Japan

来源：

VACCINE | 2008年 / 26卷 / 50期

关键词：

Confounding; Vaccination; Influenza vaccine; Randomized controlled trials; Cohort studies;

D O I：

10.1016/j.vaccine.2008.06.040

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Confounding is a kind of bias which occurs in a research. Confounding is less frequent in randomized controlled trials (RCT) for evaluation of influenza vaccines. However, there are obstacles or difficulties in conducting RCT for evaluation of influenza vaccines, particularly, in the elderly people. Therefore a retro, spective or prospective cohort study has been primarily performed to evaluate effectiveness of influenza vaccine in elderly people. Confounding by indication or other confounding exist in most observational Studies. Accordingly, at the stage of designing or analyzing a study, confounding should be controlled with a restriction, matching, stratified or multivariate analysis technique. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：6459 / 6461

页数：3

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